The most likely structure of the unknown therapy described in the given information is C) CAR-T cell augmentation.
CAR-T cell therapy is a form of immunotherapy that involves modifying a patient's own T cells to express chimeric antigen receptors (CARs). These CARs are designed to recognize and bind to specific antigens present on cancer cells, leading to their destruction. The information provided supports the likelihood of CAR-T cell augmentation as follows:
1. "Sequencing the DNA from tumors with and without treatment showed random, integrated regions of DNA": This suggests that the therapy involves genetic modification or alteration, which aligns with CAR-T cell therapy where T cells are genetically engineered to express CARs.
2. "Patient T-cells behave normally and do not showcase any special abilities against the tumors": This indicates that the therapy is not simply relying on the patient's natural T cell response but rather enhancing their capabilities through augmentation, which is a characteristic of CAR-T cell therapy.
3. "The patient immune system behaves a bit aggressively, especially after the therapy, but it's nothing major": This is consistent with the expected immune response after CAR-T cell therapy, as the modified T cells can induce an immune reaction against cancer cells, resulting in an aggressive response.
4. "The tumor cells begin dying about 1 hour after the therapy is delivered, so you can't check gene expression - Nothing is binding their surface to trigger cell death, so whatever it is, it's acting inside the cell": This suggests that the therapy is directly affecting the tumor cells internally, which is in line with the mechanism of action of CAR-T cells. The CARs expressed on the T cells recognize and activate signaling pathways inside the tumor cells, leading to their death.
5. "You detect fragments of plasmid DNA, likely the source of the somewhat-aggressive immune reaction": Plasmid DNA is commonly used in the process of engineering CAR-T cells. It serves as a vector for introducing the genetic material encoding CARs into the T cells. The presence of plasmid DNA fragments further supports the likelihood of CAR-T cell therapy.
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A powerful alien life force has just landed on Earth. Once detected, a fierce battle between the Army of Earth and the invading aliens ensues. As you read the description of the battle, relate the elements of the story to the components of the immune system. You’ll see that the roles of our immune cells and proteins directly relate to the people/tools/weapons of war!...
A Scout from the Earth Army is out patrolling the wilderness, searching for anything out of the ordinary. He suddenly stumbles upon something on the forest floor he’s never seen before so he picks it up and returns to Army headquarters. At headquarters he shows the General of the Army his secret ID (to prove he was a citizen of Earth) and the item he found. The General exclaims that the scout has found an Alien uniform! In response to this disturbing find, the General immediately sends orders to two companies of Army soldiers: a team of Chemical Warfare Specialists and a platoon of highly trained Warriors.
The Chemical Warfare Specialists take the General’s orders and the Alien uniform to their lab for further analysis. There they spend many hours developing a special toxin that only binds to Alien skin. When ready, the toxin is released by the Chemical Warfare Specialists into the atmosphere. Over the course of several days, many Aliens become incapacitated by the toxin and are forced to surrender. Meanwhile, the Warriors respond to the General's orders by infiltrating the Alien troops and battling them in hand-to-hand combat with razor-sharp swords.
Although the Earth Army suffered many casualties during the attack, they managed to save the world from alien invasion! However, knowing that more Aliens exist in the universe, the Army designates an elite group of Chemical Warfare Specialists to stand by – always prepared to make more of their alien toxin at a moment's notice in case the Alien force dares to return.
Relate the elements of this story to the components of the immune system listed below.
Match the people in the story (1-7) with the cells of the immune system (A-G).
Match the tools/weapons in the story (8-12) with the proteins involved in the immune response (H-L).
1. Earth Army _____
2. Klingons _____
3. Army scout _____
4. General of the Army _____
5. Chemical Warfare Specialists _____
6. Marine foot soldiers _____
7. elite group of Chemical Warfare Specialists _____
________________________________________
8. Secret ID of Army scout _____
9. Klingon uniform _____
10. General's orders _____
11. toxin made by Chemical Warfare Specialists ____
12. razor-sharp swords of Marines _____
A. immune system
B. B cells/plasma cells
C. memory B cells
D. cytotoxic T cells
E. helper T cells
F. antigen-presenting cells
G. pathogen
H. interleukins
I. foreign antigen
J. perforins
K. MHC proteins
L. antibodies
The immune system is very similar to the war components described in the story. In the story, the components of the immune system are the alien and the army soldiers who are fighting against each other.
The immune system comprises different types of cells and proteins that work together to identify, destroy, and remove invading pathogens from the body. The cells of the immune system can be categorized into two types: B cells and T cells. B cells are responsible for producing antibodies, while T cells are responsible for attacking and killing infected cells. The proteins of the immune system are cytokines, complement proteins, and antibodies. These proteins have different roles in the immune response. The Earth's army is analogous to the immune system because it is responsible for defending the body from invading pathogens. The following are the matches between the people in the story and the cells of the immune system:1. Earth Army: immune system2. Klingons: pathogens3. Army scout: antigen-presenting cells4. General of the Army: helper T cells5. Chemical Warfare Specialists: B cells/plasma cells6. Marine foot soldiers: cytotoxic T cells7. elite group of Chemical Warfare Specialists: memory B cells The following are the matches between the tools/weapons in the story and the proteins involved in the immune response:8. Secret ID of Army scout: foreign antigen9. Klingon uniform: pathogen10. General's orders: interleukins11. toxin made by Chemical Warfare Specialists: antibodies12. razor-sharp swords of Marines: perforins
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39 3 points In the male, LH assists in spermatogenesis and stimulates the production of: A. Secondary sexual characteristic. B.Ejaculation C. Testosterone. D. GnRH. 403 points All of the following are part of the spermatic cord, EXCEPT: A. Testicular artery B.Lymphatic vessels C. Cremaster muscle. D. Ductus deferens. E. Ejaculatory duct 41 3 points The part of the female reproductive system "lost" during menstruation is? A. Myometrium. B. Stratum functionalis of the endometrium. C. Stratum basalis of the endometrium. D. Germinal epithelium.
a. Option C is correct.
b. Option E is correct.
c. Option B is correct.
a. LH aids in spermatogenesis in males and induces the synthesis of: Testosterone, in C.
LH stimulates the generation of testosterone by acting on the Leydig cells in the testes.
b. All of the items listed here, WITH THE EXCEPTION OF: E. The urinary duct.
The structure that connects the inguinal canal to the testicles is known as the spermatic cord. It has a number of parts that supply and sustain the testes. The testicular artery, lymphatic vessels, and ductus deferens are parts of the spermatic cord.
c. The endometrium's B. stratum functionalism is the portion of the female reproductive system that is "lost" during menstruation. The endometrium's stratum functionalism sheds during menstruation. The uterus's internal lining, known as the endometrium, is made up of
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Complete question
a. In the male, LH assists in spermatogenesis and stimulates the production of:
A. Secondary sexual characteristic.
B. Ejaculation
C. Testosterone.
D. GnRH.
b. All of the following are part of the spermatic cord, EXCEPT:
A. Testicular artery
B. Lymphatic vessels
C. Cremaster muscle.
D. Ductus deferens.
E. Ejaculatory duct
c. The part of the female reproductive system "lost" during menstruation is?
A. Myometrium.
B. Stratum functionalism of the endometrium.
C. Stratum basalis of the endometrium.
D. Germinal epithelium.
The label on a candy bar says 480 Calories. Assuming a typical efficiency for energy use by the body, if a 62 person were to use the energy in this candy bar to climb stairs, how high could she go?
A person weighing 62 kg could climb approximately 224 meters using the energy from a candy bar with 480 Calories.
To calculate the height that can be climbed using the energy from the candy bar, we need to consider the energy efficiency of the human body during physical activity. On average, the efficiency is around 20-25%. This means that only a fraction of the energy consumed is actually used for mechanical work, while the rest is lost as heat.
The energy content of the candy bar is given as 480 Calories. However, 1 Calorie is equal to 1 kilocalorie (kcal), which is equivalent to 4.184 kilojoules (kJ). So, the candy bar provides 480 kcal or 480 * 4.184 = 2003.52 kJ of energy.
Now, let's calculate the work done while climbing stairs. On average, climbing stairs burns approximately 0.25 kJ of energy per kilogram of body weight per meter climbed. So, for a person weighing 62 kg, they would burn 0.25 * 62 = 15.5 kJ per meter climbed.
To find the height that can be climbed, we divide the total energy provided by the candy bar (2003.52 kJ) by the energy expended per meter climbed (15.5 kJ/m). This gives us 2003.52 / 15.5 = 129.27 meters.
Therefore, a person weighing 62 kg could climb approximately 129 meters using the energy from the candy bar. However, since the efficiency of energy use by the body is typically around 20-25%, we need to divide this result by that efficiency factor. This gives us 129 / 0.25 = 516 meters.
Thus, a 62 kg person could climb approximately 516 meters using the energy from the candy bar, taking into account the typical energy efficiency of the body during physical activity.
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The chemical called EDTA chelates calcium ions? Explain at which
level in the pathway, and why EDTA would affect blood
clotting!
EDTA (ethylenediaminetetraacetic acid) is a chelating agent that can form stable complexes with metal ions such as calcium, which is required for blood clotting. EDTA would therefore affect blood clotting by chelating calcium ions and rendering them unavailable for the coagulation cascade.
EDTA affects blood clotting at the level of coagulation cascade. Calcium ions play an important role in blood coagulation by acting as a cofactor in the activation of several clotting factors, including Factor X, prothrombin, and Factor VII. Therefore, if calcium is chelated by EDTA, it is unable to act as a cofactor, resulting in decreased blood clotting.
EDTA would affect blood clotting because it can chelate calcium ions. Calcium is an essential cofactor in blood clotting; it is required for the activation of several clotting factors. When calcium is chelated by EDTA, it is no longer available to act as a cofactor, which can lead to decreased clotting activity. Therefore, EDTA may be used as an anticoagulant by removing calcium ions from the clotting reaction.
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Timer 17. Which of the following structures of the brain is NOT connected to the reticular formation? Medulla Hypothalamus Substantia niagra Cerebellum Red nucleus Unaved save > O
The structure of the brain that is NOT connected to the reticular formation is the cerebellum. The cerebellum is located at the back of the brain and is responsible for coordination and balance. It helps to maintain posture and balance and is involved in the coordination of voluntary movements.
The medulla, hypothalamus, substantia niagra, and red nucleus are all connected to the reticular formation. The medulla oblongata is a part of the brainstem that controls many vital functions such as breathing and heart rate. The hypothalamus is involved in regulating many bodily functions including body temperature, hunger, thirst, and sleep. The substantia niagra is a part of the midbrain that is involved in the production of dopamine, a neurotransmitter that is involved in the control of movement. The red nucleus is another part of the midbrain that is involved in the control of movement.
Therefore, the cerebellum is the only structure of the brain among the given options that is NOT connected to the reticular formation.
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Describe a situation where utilizing predictive 1RM tests would
be applicable.
Predictive 1RM tests can be used in several situations, including creating training plans, tracking progress, and identifying strength imbalances.
However, a situation where utilizing predictive 1RM tests would be applicable is to determine the training intensity of a client who wants to increase their strength. A client wants to increase their strength, and you, as a trainer, want to determine the appropriate training intensity for them. To do this, you need to estimate the client's 1-rep max (1RM), which is the maximum weight they can lift for one repetition. However, testing a client's 1RM can be risky, especially if the client is new to lifting weights or lacks experience. So, in this situation, you can use predictive 1RM tests to estimate the client's 1RM. This test involves using a submaximal weight and calculating the predicted 1RM using an equation such as Epley's or Brzycki's formula. The result will give you a good idea of the client's strength level, which will help you design an appropriate training program that will help the client increase their strength while minimizing the risk of injury.
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What direct effect, if any, does Aldosterone have on the following?
A) sodium retention in the kidneys.
C) blood volume.
D) urinary sodium.
E) pH regulation.
Aldosterone is a hormone that is produced by the adrenal cortex, which is a part of the adrenal gland. Aldosterone has a direct effect on sodium retention in the kidneys. When aldosterone is present, it enhances the absorption of sodium ions in the kidney tubules, which results in an increase in sodium retention by the kidneys.
This is important for maintaining electrolyte balance in the body and regulating blood pressure. The direct effect of aldosterone on the other options is as follows:C) Blood volume: Aldosterone indirectly affects blood volume by regulating the retention of sodium ions in the kidneys. An increase in sodium retention leads to an increase in blood volume.D) Urinary sodium: Aldosterone decreases the amount of sodium that is excreted in urine. This is because it increases the reabsorption of sodium in the kidney tubules.E) pH regulation: Aldosterone has no direct effect on pH regulation. It primarily affects sodium and electrolyte balance in the body. However, changes in sodium and electrolyte balance can indirectly affect pH regulation.
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e. coli cells are grown for many generations in heavy 15n precursors, then moved to light 14n precursors for two generations. the dna is purified, broken into linear pieces, and run in an equilibrium density gradient. two bands form. what is found within the top band? e. coli cells are grown for many generations in heavy 15n precursors, then moved to light 14n precursors for two generations. the dna is purified, broken into linear pieces, and run in an equilibrium density gradient. two bands form. what is found within the top band? single strands of 15n dna double-stranded 15n dna double-stranded 14n/15n (hybrid) dna double-stranded 14n dna single strands of 14n dna
E. coli cells are grown in heavy 15n precursors, then switched to light 14n precursors for two generations. After purifying the DNA, breaking it into linear pieces, and running it in an equilibrium density gradient, two bands are formed. The top band contains single strands of 14n DNA.
During the growth of E. coli cells in heavy 15n precursors, the DNA in the cells incorporates the heavy nitrogen isotope (15n). When the cells are switched to light 14n precursors, the DNA replicated during subsequent generations will contain the lighter nitrogen isotope (14n). The DNA is then purified and broken into linear pieces.
When these pieces are run in an equilibrium density gradient, two bands are formed. The top band represents DNA that is lighter and migrates faster in the gradient, which corresponds to single strands of 14n DNA. The bottom band contains the heavier DNA, either double-stranded 15n DNA or double-stranded 14n/15n (hybrid) DNA.
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Anticholinergic is the Aggregating of toxic agents and physical findings to rapidly detect the suspected cause such as pesticide and insecticides and consideration of physical symptoms due to this toxins such as wet man presentation Select one: True False
Anticholinergic is the Aggregating of toxic agents and physical findings to rapidly detect the suspected cause such as pesticide and insecticides and consideration of physical symptoms due to this toxins such as wet man presentation, the given statement is false because anticholinergic is a term used for medicines that block the action of acetylcholine in the body.
It is used in the treatment of diseases such as asthma, chronic obstructive pulmonary disease (COPD), and overactive bladder. They help in relaxing the muscles of the airways, bladder, and intestines by blocking the neurotransmitter acetylcholine at the receptor sites. Anticholinergic medicines are not used for the detection of suspected toxins such as pesticides and insecticides in the body. They do not have any role in aggregating toxic agents and physical findings to rapidly detect the suspected cause of toxicity.
They are used for therapeutic purposes, and their mechanism of action is different from that of toxic agents. Anticholinergic toxicity can occur if a patient takes an overdose of anticholinergic medications. Symptoms of anticholinergic toxicity include dry mouth, blurred vision, dizziness, constipation, confusion, and urinary retention. Therefore, the given statement is false.
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Laboratory Review Worksheet Part 1: Lab Q & A 1. What is the difference between the zygomatic process and the zygomatic arch? 2. List the four cranial bones that contain sinuses. 1.... 2.... 3..... 4..... 3. What are the two main functions of fontanelles? 1.... 2.... 4. Fill in the table. Structure Significance 1. Passageway for the internal carotid artery
Foramen magnum 2. Passageway for 3. Passageway for cranial nerve
Optic canal 4. Passageway for 5. Choose which type of vertebrae has the characteristic (select choices more than once) a. Cervical b. Thoracic c. Lumbar d. All a, b, and c 1. Transverse foramen 2. Costal facets 3. Bifid (split) spinous process 4. Broad, flat spinous process 6. An excessive thoracic curvature of the spine is known as a. lordosis b. kyphosis C. scoliosis 7. Which intervertebral ligament attaches to the posterior portion of each vertebral body? a. interspinous c. supraspinous b. anterior longitudinal d. posterior longitudinal
1. The zygomatic process is part of the zygomatic arch.
2. The frontal, ethmoid, sphenoid, and maxillary bones contain sinuses.
3. Fontanelles allow skull flexibility during childbirth and accommodate brain growth in infants.
4. Structures like the foramen magnum and optic canal serve as passageways for arteries, nerves, and cerebrospinal fluid.
5. Different types of vertebrae have distinct features, such as transverse foramen in cervical vertebrae and costal facets in thoracic vertebrae.
6. Excessive thoracic curvature is called kyphosis.
7. The supraspinous ligament attaches to the posterior vertebral bodies.
1. The zygomatic process is a projection of the temporal bone that forms part of the zygomatic arch. The zygomatic arch, on the other hand, is a bony structure formed by the temporal bone and the zygomatic bone. In summary, the zygomatic process is a component of the zygomatic arch.
2. The four cranial bones that contain sinuses are:
1. Frontal bone
2. Ethmoid bone
3. Sphenoid bone
4. Maxillary bone
3. The two main functions of fontanelles (also known as "soft spots") are:
1. Allow for flexibility and compression of the skull during childbirth.
2. Accommodate rapid brain growth in infants by providing room for brain expansion.
4. Structure Significance
1. Foramen magnum Passageway for the internal carotid artery and the spinal cord.
2. Optic canal Passageway for the optic nerve and ophthalmic artery.
3. Cranial nerve Passageway for various cranial nerves.
4. Fourth ventricle Passageway for cerebrospinal fluid (CSF) circulation.
5. The characteristic features of the different types of vertebrae are as follows:
- Cervical: Transverse foramen, bifid (split) spinous process.
- Thoracic: Costal facets, long and downward-pointing spinous process.
- Lumbar: Broad, flat spinous process.
- All a, b, and c: Cervical, thoracic, and lumbar vertebrae share some of these characteristics.
6. An excessive thoracic curvature of the spine is known as **b. kyphosis**. Lordosis refers to excessive inward curvature of the lumbar spine, while scoliosis is an abnormal lateral curvature of the spine.
7. The intervertebral ligament that attaches to the posterior portion of each vertebral body is the **c. supraspinous** ligament. The anterior longitudinal ligament attaches to the anterior portion of the vertebral bodies, the posterior longitudinal ligament runs within the vertebral canal along the posterior aspect of the vertebral bodies, and the interspinous ligament connects adjacent spinous processes.
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Explain how early colonial government worked in the Middle Colonies. Hogg go at C Zac
During the early colonial period, the Middle Colonies, consisting of present-day New York, New Jersey, Pennsylvania, and Delaware, had a unique system of government that was influenced by both English and Dutch traditions.
The colonial governments in the Middle Colonies exhibited certain characteristics that set them apart from other regions.
One notable aspect of early colonial government in the Middle Colonies was the presence of diverse religious and ethnic groups. Unlike the New England colonies, which were primarily Puritan, and the Southern colonies, which were dominated by Anglicans, the Middle Colonies were home to a mix of religious denominations, including Quakers, Catholics, Lutherans, and Jews, among others. This religious diversity influenced the development of more tolerant and inclusive forms of governance.
The Middle Colonies typically had a two-tiered system of government. At the local level, each colony was divided into counties, which were further divided into townships. These local governments had elected officials, such as sheriffs, justices of the peace, and township supervisors, who were responsible for maintaining law and order, settling disputes, and overseeing local affairs.
At the colonial level, each Middle Colony had a governor appointed by the English monarchy or proprietary owners. The governor held executive authority and was responsible for representing the interests of the crown or proprietors. However, the governors' power was often balanced by the presence of an elected colonial assembly, which represented the interests of the colonists. The assemblies were composed of representatives chosen by eligible male landowners or freemen, and they had the authority to pass laws, levy taxes, and make decisions on behalf of the colony.
The Middle Colonies had a greater degree of religious and political freedom compared to other regions. Pennsylvania, in particular, established by William Penn as a Quaker colony, was known for its commitment to religious tolerance and democratic principles. The colony implemented a unique framework called the "Great Law" that provided for representative government, fair treatment of Native Americans, and freedom of religion.
Overall, early colonial government in the Middle Colonies reflected a blend of English and Dutch influences, with an emphasis on religious tolerance, local self-governance, and representative assemblies. This system of government laid the foundation for the democratic traditions that would later shape the United States.
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What is the best definition for mineral nutrients?
1. Inorganic substances required for life
2. Organic substances required for life
3. Micronutrient substances required for life
4. Macronutrient substances required for life
The best definition for mineral nutrients is that they are inorganic substances required for life.The correct answer is option 1.
Mineral nutrients are inorganic nutrients that are vital for proper health, growth, and development. They're known as essential minerals since they're required for a variety of bodily processes that sustain life. Some of these nutrients play a significant role in various physiological functions, such as electrolyte regulation, cell function, blood clotting, and bone strength.Most of the minerals that humans need can be found in the soil and in the foods that we eat. However, some people may not consume enough of certain minerals, such as iron or calcium, in their diets, leading to mineral deficiencies. In these instances, doctors may recommend mineral supplements to help correct the deficiency.The correct answer is option 1.
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Which of the following statements about protein synthesis is NOT TRUE? a. Transcription occurs in the ribosome of the cell. b. DNA directs the cell to carry out the process. c. RNA is single-stranded and travels outside the nucleus. d. In RNA, the pyrimidine base thymine is replaced with uracil.
The following statement about protein synthesis that is NOT TRUE is "Transcription occurs in the ribosome of the cell."
What is protein synthesis?Protein synthesis is a process by which biological cells produce new proteins. The process takes place in two stages: transcription and translation.The correct options are:a. Transcription occurs in the ribosome of the cell - False. Transcription is the process by which a DNA sequence is converted into an RNA molecule. This process occurs in the cell nucleus and not the ribosome of the cell.
DNA directs the cell to carry out the process - True. DNA contains the genetic code that directs the synthesis of proteins in the cell. RNA is single-stranded and travels outside the nucleus - True. RNA is single-stranded and travels outside the nucleus, to the ribosome, where protein synthesis occurs.
In RNA, the pyrimidine base thymine is replaced with uracil - True. RNA contains four nitrogenous bases, adenine (A), guanine (G), cytosine (C), and uracil (U). RNA does not contain thymine (T). It is replaced by uracil (U).Therefore, the correct answer is: a. Transcription occurs in the ribosome of the cell.
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Two equal volumes of liquid are added to a chamber, separated by a semipermeable membrane. Water molecules (and only water molecules) can pass easily through the membrane. On one side (Side A) the liquid is pure water. On the other (Side B) the solution contains a high concentration of salt (NaCl) in water. After two hours, you observe that the water level on Side B is higher than on Side A. Which of the following best explains this result? O Water molecules repel each other, and diffuse away from areas of high concentration of water O Solute particles bound to water molecules, move away from a membrane impermeable to the solute, pulling water molecules across the membrane permeable to water. O Water molecules attract each other, and form bonds between water molecules that are stronger than those between water and the solute particles, drawing water toward areas of high solute concentration where water-solute bonds break and water-water bonds form. O Water molecules form stronger bonds with solute particles, than with neighboring water molecules, pulling water molecules across the membrane toward high concentrations of solute particles.
After two hours, you observe that the water level on Side B is higher than on Side A. The statement (c) is the best explains this result.
This observation can be best explained as follows: Water molecules attract each other, and form bonds between water molecules that are stronger than those between water and the solute particles, drawing water toward areas of high solute concentration (The substance that dissolves in a solution is called the solute, and the substance that does the dissolving is called the solvent. The concentration of a solution is the amount of solute in a given amount of solution) where water-solute bonds break and water-water bonds form. In this scenario, water molecules attract each other and form hydrogen bonds. This hydrogen bonding is why the water level in side B is higher than side A.
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The full question is
Two equal volumes of liquid are added to a chamber, separated by a semipermeable membrane. Water molecules (and only water molecules) can pass easily through the membrane. On one side (Side A) the liquid is pure water. On the other (Side B) the solution contains a high concentration of salt (NaCl) in water. After two hours, you observe that the water level on Side B is higher than on Side A. Which of the following best explains this result?
(A) Water molecules repel each other, and diffuse away from areas of high concentration of water
(b) Solute particles bound to water molecules, move away from a membrane impermeable to the solute, pulling water molecules across the membrane permeable to water.
(c) Water molecules attract each other, and form bonds between water molecules that are stronger than those between water and the solute particles, drawing water toward areas of high solute concentration where water-solute bonds break and water-water bonds form.
(D) Water molecules form stronger bonds with solute particles, than with neighboring water molecules, pulling water molecules across the membrane toward high concentrations of solute particles.
Mr Lambert consults you about pain in the sides; during the visit, you take note of the following signs: fatigue, discouragement - fever and shivers – irregular stools – dark urine - nausea, vomiting – bitter mouth, coated tongue – bad breath
Choose the right energetic diagnosis
A Deficient yang of the kidney
B Blocked Qi of the liver
C Hyperactive yang of the liver
D Humidity-heat liver-gall bladder
The correct energetic diagnosis based on the given signs including fatigue and discouragement, fever and shivers, irregular stools, dark urine, nausea and vomiting, bitter mouth, coated tongue, and bad breath is the Humidity-heat liver-gall bladder. The answer is (D).
The liver and gallbladder regulate Qi and are responsible for the smooth flow of emotions in the body. When the liver fails to regulate the emotional states, it can cause it to stagnate and accumulate, resulting in a blockage. Hence, the blocked Qi of the liver can be seen as irritability, depression, and general feelings of frustration.
The problem described here involves fever and shivers, nausea and vomiting, dark urine, bitter mouth, coated tongue, and bad breath. This suggests a condition of humidity-heat affecting the liver-gall bladder. This is particularly true when accompanied by fatigue and discouragement. Therefore, the correct energetic diagnosis is D. Humidity-heat liver-gall bladder.
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Question 11 2 pts Based on the baroreceptor reflex, state how the following would respond due to a decrease in blood pressure: [ Select] Stretch of Baroreceptors [ Select] Firing of Action potentials [ Select] Vasomotor Center [ Select] Cardio Acceleratory Center [ Select] Blood vessel diameter [ Select] Heart Rate [ Select] Stroke Volume
[ Select]Cardiac Output [ Select] Blood Pressure [ Select] : increase/decrease
Based on the baroreceptor reflex, stretch of baroreceptors would respond due to a decrease in blood pressure.
What is the baroreceptor reflex?
The baroreceptor reflex is a feedback loop that assists in the maintenance of blood pressure. It is a negative feedback system that operates in response to changes in blood pressure.
The baroreceptor reflex's primary goal is to maintain a steady blood pressure despite fluctuations in vascular resistance and cardiac output.
In the event of a decrease in blood pressure:
Stretch of Baroreceptors: It decreases the firing of action potentials. This is caused by reduced stretching of the carotid arteries' and aortic arches' baroreceptors, which detect changes in arterial pressure. The stimulation frequency of the afferent fibers reduces as baroreceptor activity decreases.
Vasomotor Center: It will respond by increasing sympathetic activity. When the baroreceptors detect a decrease in blood pressure, they generate less action potential activity, leading to a decrease in the frequency of inhibitory signals transmitted to the vasomotor center. This, in turn, increases sympathetic activity.
Cardio Acceleratory Center: It will be activated to increase cardiac output. A decrease in cardiac output activates the cardiac accelerator center in the medulla, which raises sympathetic activity and increases heart rate, contractility, and peripheral vascular resistance.
Blood Vessel Diameter: It decreases, as the sympathetic nervous system is activated, and vasoconstriction occurs, causing a decrease in vessel diameter.
Heart Rate: It increases due to sympathetic nervous system stimulation, leading to a rise in heart rate.
Stroke Volume: It increases because the increase in heart rate causes the heart to pump more blood.
Cardiac Output: It increases due to the increased heart rate and stroke volume.
Blood Pressure: It increases as a result of the increase in cardiac output and peripheral vascular resistance.
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zheng js, tang s, qi yk, wang zp, liu l (2013) chemical synthesis of proteins using peptide hydrazides as thioester surrogates. nat protoc 8(12):2483–2495.
The protocol outlines a thorough process for the native chemical ligation of peptide hydrazides to produce proteins.
A set of techniques known as chemical ligation is used to create long peptide or protein chains. In a convergent approach, it follows the first step. First, conventional chemical peptide synthesis produces smaller peptides between 30 and 50 amino acids in length. After that, they are completely vulnerable. Recombinant protein C-terminal thioesters often interact with synthetic peptides containing N-cysteine in a chemoselective ligation as part of the expressed protein ligation method for protein semisynthesis.
A simple method can be used to directly synthesise native backbone proteins of average size. The chemoselective reaction of two unprotected peptide segments results in the production of an initial thioester-linked species. This fleeting intermediate undergoes a spontaneous rearrangement to give rise to a fully developed product with a native peptide bond at the location of ligation.
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Complete Question:
Explain the chemical synthesis of proteins using peptide hydrazides as thioester surrogates. nat protoc 8(12):2483–2495. zheng js, tang s, qi yk, wang zp, liu l (2013)
The amount of testosterone and sperm produced by the testes is dependent on the influence of?
The amount of testosterone and sperm produced by the testes is dependent on the influence of the hypothalamus-pituitary-gonadal (HPG) axis.
The hypothalamus secretes gonadotropin-releasing hormone (GnRH), which stimulates the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH).These hormones act on the testes, encouraging testosterone and sperm production. The amount of testosterone and sperm produced in the testes is also influenced by the presence of Leydig and Sertoli cells. Leydig cells are responsible for producing testosterone, while Sertoli cells assist in the maturation of sperm.
The production of testosterone and sperm is tightly regulated by feedback mechanisms within the HPG axis. When testosterone levels are low, the hypothalamus releases more GnRH, which stimulates the pituitary gland to secrete FSH and LH, thereby increasing testosterone and sperm production. Conversely, high levels of testosterone exert negative feedback on the hypothalamus and pituitary, leading to a decrease in GnRH, FSH, and LH release, and subsequently reducing testosterone and sperm production.
Overall, the HPG axis serves as a regulatory system controlling the production of testosterone and sperm, maintaining the balance necessary for male reproductive function.
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A. 45 -year -old female with a history of Type I diabetes mellitus developed marked proteinuria. What is the most likely histological finding in her kidney? A. Reflux nephropathy B. Diabetic nephropathy C. Acute Glomerulonephritis D. Nodular mesangial glomerulopathy
The most likely histological finding in the kidney of a 45-year-old female with a history of Type I diabetes mellitus and marked proteinuria is Diabetic nephropathy. Option B .
Diabetic nephropathy is a microvascular complication of diabetes that involves the kidney. It is caused by damage to the small blood vessels in the kidneys that are used to filter waste from the blood. Diabetic nephropathy, or diabetic kidney disease, is the leading cause of end-stage renal disease (ESRD) in the United States and other developed countries.
It is also a major cause of morbidity and mortality in people with diabetes. Therefore, the most likely histological finding in the kidney of a 45-year-old female with a history of Type I diabetes mellitus and marked proteinuria is Diabetic nephropathy. Option B is correct.
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How is the lagging strand built during DNA replication?
Explanation:
The leading strand is synthesized by adding nucleotides to the 3' end of the growing strand, and the lagging strand is synthesized by adding nucleotides to the 5' end. The lagging strand is synthesized continuously, whereas the leading strand is synthesized in short fragments that are ultimately stitched together.
Systematically explain the functional significance of different
parts of the brain
The brain consists of the cerebral cortex, limbic system, basal ganglia, thalamus, brainstem, cerebellum, and corpus callosum, which collaboratively enable cognitive processes, emotional responses, motor control, sensory perception, and information integration.
Different parts of the brain are Cerebral Cortex, Limbic System, Basal Ganglia, Thalamus, Brainstem, Cerebellum, and Corpus Callosum.
The brain is a complex organ that consists of various parts, each with its own unique functions. Here is a systematic explanation of the functional significance of different parts of the brain:
Cerebral Cortex: The cerebral cortex is the outer layer of the brain and is responsible for higher cognitive functions such as thinking, reasoning, perception, and voluntary movement. It is divided into four lobes: frontal, parietal, temporal, and occipital. Each lobe has specific roles, for example:
Frontal lobe: It is involved in decision-making, problem-solving, and motor control.
Parietal lobe: It processes sensory information, spatial awareness, and perception.
Temporal lobe: It plays a role in memory, language processing, and auditory perception.
Occipital lobe: It is primarily responsible for visual processing.
Limbic System: The limbic system is a group of structures located deep within the brain and is involved in emotion, memory, and motivation.
Key components include the hippocampus (memory formation), amygdala (emotion and fear processing), and hypothalamus (regulation of basic drives like hunger, thirst, and sexual behavior).
Basal Ganglia: The basal ganglia are a group of structures involved in motor control, procedural learning, and habit formation. They help initiate and regulate voluntary movements and are also implicated in Parkinson's disease and other movement disorders.
Thalamus: The thalamus acts as a relay station for sensory information, directing signals to the appropriate areas of the cerebral cortex for processing. It is crucial for sensory perception, attention, and consciousness.
Brainstem: The brainstem is the oldest and most primitive part of the brain, responsible for vital functions necessary for survival, including regulating heartbeat, breathing, and maintaining basic levels of consciousness. It comprises the midbrain, pons, and medulla oblongata.
Cerebellum: The cerebellum is located at the back of the brain, below the cerebral cortex. It plays a critical role in coordinating and fine-tuning motor movements, maintaining balance and posture, and motor learning.
Corpus Callosum: The corpus callosum is a bundle of nerve fibers that connects the left and right hemispheres of the brain. It facilitates communication and information exchange between the two hemispheres, enabling integration of sensory and motor functions.
It's important to note that this is a simplified overview, and each brain region interacts with others to support complex cognitive and physiological processes.
The brain's functional significance arises from the intricate connections and interactions between these various parts, allowing for the integration of information, control of bodily functions, and the basis of our cognitive abilities.
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USLIIS 10 point Montal contrasting is the strategy for setting goals which includes both Vividly imagining the future outcome you would like to achieve and all the good things that can accompany it . Focusing on all of the obstacles that could potentially got in the way of accomplishing their goals O True
O False
The statement "USLIIS 10 point Montal contrasting is the strategy for setting goals which includes both Vividly imagining the future outcome you would like to achieve and all the good things that can accompany it . Focusing on all of the obstacles that could potentially got in the way of accomplishing their goals" is false. SO the given statement is false
The USLIIS 10 point system is a goal-setting system. It helps you in defining your objectives and objectives that you want to attain with regards to your profession. It can be used in both personal and professional situations to help you reach your goals. The system is made up of ten key elements, each of which is designed to assist you in defining your objectives and making progress toward them. Contrasting is a technique that was created by the German philosopher Oettingen. It's a two-step procedure for reaching one's goals.
People who want to achieve a goal use this strategy by first visualizing the positive future outcome they want to attain, and then imagining all the obstacles that could get in the way of achieving that goal. The procedure of Contrasting is not linked with the USLIIS 10 point system. It is a part of Mental Contrasting with Implementation Intentions (MCII). Therefore, the statement given in the question is false.
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Problem #4. Jane has returned to the gym in the new year hoping to get back in shape and add some new muscle. She knows from her anatomy and physiology class that to gain muscle (protein) she must eat protein, even though she is a vegetarian. Her favorite food after working out is rice and beans (complete protein). Her digestive system takes the complete protein she has eaten and breaks it into individual amino acids (hydrophilic) - Trace the amino acids as they are a) picked up by the superior mesenteric vein and delivered back to the heart for distribution, and then b) pumped out to the right bicep muscle so that Jane may impress her friends with her toned and shapely arms. Remember the Rules of the Game, and also the special role our liver plays when we orally ingest some substances
After digestion, amino acids from complete protein are absorbed into the bloodstream through the superior mesenteric vein, delivered to the heart for distribution, and then transported to the right bicep muscle to aid in muscle growth.
After Jane consumes rice and beans (complete protein), her digestive system breaks down the protein into individual amino acids, which are hydrophilic (water-soluble). These amino acids are absorbed through the lining of the small intestine and enter the bloodstream.
The absorbed amino acids, along with other nutrients, are picked up by the superior mesenteric vein, a blood vessel that drains the intestines. The superior mesenteric vein carries the amino acids to the liver, where they undergo further processing and regulation.
From the liver, the amino acids are delivered back into the bloodstream and transported to the heart. The heart then pumps the blood, carrying the amino acids, to various parts of the body for distribution, including the right bicep muscle.
In the right bicep muscle, the amino acids are taken up by the muscle cells and utilized for protein synthesis, aiding in muscle growth and repair. The liver plays a crucial role in regulating nutrient levels in the bloodstream. It processes and metabolizes amino acids, converting them into forms that can be utilized by the body or stored for future use.
Overall, the digestive system breaks down complete protein into amino acids, which are then absorbed into the bloodstream.
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The rectus abdominis muscle: a. Concentrically causes the spine to move in the sagital plane.
b. Eccentrically controls lumbar flexion.
c. Is the best abdominal muscle to produce spine rotation.
d. Is part of a force couple to produce an anterior pelvic tilt.
Option C: The rectus abdominis muscle is the best abdominal muscle to produce spine rotation.
The rectus abdominis muscle, commonly known as the "six-pack" muscle, is a paired muscle that runs vertically along the front of the abdomen. While it does have other functions, such as providing core stability and assisting in maintaining posture, it is primarily responsible for spinal flexion and rotation.
During spine rotation, the rectus abdominis muscle on one side contracts concentrically while the opposite side contracts eccentrically, creating a twisting motion. This action allows the spine to rotate in the transverse plane, which is the plane of movement where rotation occurs. Therefore, it is indeed the primary muscle involved in spine rotation.
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An otherwise healthy, 72 year-old man has had increasing difficulty with urination for the past 10 years. He now has to get up several times each night because of a feeling of urgency, but each time the urine volume is not great. He has difficulty starting and stopping urination. On physical examination, the prostate is enlarged to twice its normal size. One year ago, his serum prostate specific antigen (PSA) level was 6 ng/mL, and it is still at that level when retested. Which of the following is the most likely diagnosis?
(Normal range of PSA: Men aged 70 and above: 0 to 5.0 ng/mL for Asian Americans, 0 to 5.5 ng/mL for African Americans, and 0 to 6.5 ng/mL for Caucasians)
a) Prostate cancer
b) Hydrocele
c) Benign prostatic hyperplasia
d) Orchitis
The correct option is c) Benign prostatic hyperplasia (BPH). Based on the given information, the most likely diagnosis for this 72-year-old man is Benign prostatic hyperplasia (BPH).
Benign prostatic hyperplasia (BPH) is the most probable diagnosis for an otherwise healthy 72-year-old man who has had increasing difficulty with urination for the past ten years. BPH, prostate cancer, hydrocele, and orchitis are all distinct medical illnesses. BPH is a benign (non-cancerous) growth of the prostate gland's epithelial and stromal components.
The prostate, located beneath the bladder in males, produces semen components that help maintain the sperm in liquid form and prevent the immune system from attacking them. An enlarged prostate gland caused by BPH can impede the normal flow of urine, resulting in incomplete bladder emptying, weak urine flow, and other related symptoms. The prostate-specific antigen (PSA) blood test, which measures PSA levels in the blood, can help determine if the man is suffering from BPH or prostate cancer.
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Case 1 Kim is a 10-year-old girl who presents to the urgent care clinic with a 14-day history of nasal stuffiness, copious amounts of green nasal drainage, fever, generalized headache ("my whole head hurts"), facial pain above and below the eyes, and fatigue. Kim reports that her younger sister recently had a "bad cold"; no one else in the family is currently ill. Kim's medical history is significant for seasonal allergies, usually flaring up this time of the year. Kim has been using her antihistamine medication to block the seasonal allergies, but this treatment has not been effective. Kim's mother reports that Kim is constantly stressed out and puts way too much pressure on herself." Kim says that her biggest concern is missing the school musical; she is the lead and the opening production is in 2 days. Upon physical examination, Kim has an oral temperature of 100.4°F. The practitioner taps gently above and below Kim's eyes; her sinuses are tender when touched. The lymph glands along her neck are enlarged and tender. Kim undergoes sinus radiographs (X-rays). The radiographs indicate fluid accumulation in the frontal and maxillary sinuses. Kim is diagnosed with sinusitis, related to a persistent upper respiratory infection. Kim is prescribed a 3-week course of antibiotics to treat the sinus infection. 1. Would you define Kim as healthy or ill? Explain. 2. What risk factors does Kim have that could have led to the development of the sinusitis? 3. What is the etiology of Kim's sinusitis? Would the sinusitis be considered either nosocomial or iatrogenic? Explain. 4. Identify the symptoms that Kim reports. 5. Identify the signs leading to the diagnosis of sinusitis. 6. How would you categorize this illness: acute or chronie? Explain. 7. Which of the manifestations are local and which are systemic? 8. What is the prognosis for Kim? 9. What aspects related to human diversity and disease would be important to consider with
1. Kim is ill.
2. Risk factors: recent upper respiratory infection, history of seasonal allergies, exposure to sister with a "bad cold."
3. Etiology: bacterial infection related to persistent upper respiratory infection; not nosocomial or iatrogenic.
4. Symptoms: nasal stuffiness, copious nasal drainage, fever, headache, facial pain, fatigue.
5. Signs: sinus tenderness, enlarged and tender lymph glands, fluid accumulation in sinuses.
6. This illness is acute sinusitis.
7. Local manifestations: sinus tenderness, facial pain; systemic manifestations: fever, headache, fatigue.
8. The prognosis for Kim is generally good with appropriate treatment.
9. Considerations: cultural and socioeconomic factors, individual stress responses, and impact on the immune system.
1. Kim would be considered ill. She is experiencing symptoms such as nasal stuffiness, copious nasal drainage, fever, headache, facial pain, and fatigue, which are indicative of an infection or illness.
2. The risk factors that could have led to the development of sinusitis in Kim include her recent upper respiratory infection, her history of seasonal allergies, and her exposure to her younger sister who had a "bad cold." Additionally, stress and pressure can weaken the immune system and make individuals more susceptible to infections.
3. The etiology of Kim's sinusitis is likely a bacterial infection resulting from a persistent upper respiratory infection. Sinusitis, in this case, would not be considered nosocomial (acquired in a healthcare setting) or iatrogenic (resulting from medical treatment).
4. The symptoms that Kim reports include nasal stuffiness, copious nasal drainage, fever, generalized headache, facial pain above and below the eyes, and fatigue.
5. The signs leading to the diagnosis of sinusitis include tenderness of the sinuses upon palpation, enlarged and tender lymph glands along the neck, and fluid accumulation in the frontal and maxillary sinuses observed on the sinus radiographs.
6. This illness would be categorized as acute sinusitis since Kim's symptoms have been present for 14 days. Chronic sinusitis typically persists for longer periods, usually more than 12 weeks.
7. The manifestations of sinusitis can be both local and systemic. Local manifestations include nasal stuffiness, nasal drainage, facial pain, and sinus tenderness. Systemic manifestations include fever, headache, and fatigue.
8. The prognosis for Kim is generally good with appropriate treatment. With a 3-week course of antibiotics, her sinus infection is likely to resolve, and she can recover from her symptoms.
9. Regarding human diversity and disease, it would be important to consider any cultural or socioeconomic factors that may impact Kim's access to healthcare, adherence to medication, and understanding of the illness. Additionally, understanding her individual response to stress and its impact on her immune system could be relevant.
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Which of the following may increase the risk of breast cancer? a. Early menopause b. Having more than 3 children c. Becoming obese after menopause d. Breastfeeding
c) Becoming obese after menopause may increase the risk of breast cancer. Adipose tissue produces estrogen, and higher levels of estrogen after menopause can promote the development of breast cancer cells.
Becoming obese after menopause is associated with an increased risk of breast cancer. Adipose tissue, particularly in postmenopausal women, is a significant source of estrogen production. Estrogen can stimulate the growth of certain types of breast cancer cells. When women go through menopause, the ovaries produce less estrogen. However, adipose tissue continues to produce estrogen through the conversion of androgens to estrogen by the enzyme aromatase. With increased adiposity, there is a higher level of estrogen production, which can promote the development and growth of breast cancer cells. Therefore, obesity after menopause is considered a risk factor for breast cancer. It is important to note that other factors, such as genetics, hormonal factors, and lifestyle choices, can also influence breast cancer risk, and the interplay between these factors is complex.
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During a push up, indicate the plane and axis for each joint
(shoulder, elbow, hand/wrist).
During a push-up, the plane and axis for each joint is as follows:Shoulder Joint: The plane of movement for the shoulder joint during a push-up is sagittal, which is also referred to as the anteroposterior plane.
The axis of rotation is in a horizontal plane that passes through the joint center. This axis is also known as the mediolateral axis.Elbow Joint: The plane of movement for the elbow joint during a push-up is sagittal. The axis of rotation is in the frontal plane that passes through the joint center. This axis is also known as the anteroposterior axis.Hand/Wrist Joint: The plane of movement for the hand/wrist joint during a push-up is transverse, which is also referred to as the horizontal plane. The axis of rotation is in a longitudinal plane that passes through the joint center. This axis is also known as the vertical axis.
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DNA and RNA both use the same types of nucleotides
Answer:
No
Explanation:
In the nucleotide of DNA and RNA only Phosphate that is similar to both nucleic acid, They have different sugar portion and Nitrogenous base.
DNA nucleotide include
- Phosphate
- deoxyribose sugar
- NB Adenine, Thymine, Guanine and Cytosine
RNA nucleotide include
- Phosphate
- Ribose sugar
- NB Adenine, Uracil, Guanine and Cytosine
Therefore They do not use the same types of nucleotides because DNA has 2 strand that are joined together by weak hygrogen bond and it is long. while RNA has 1 strand and it is a short thus not coiled or helical.
Nyasha suffers from bulimia in the novel, Nervous
Conditions. Identify two other "nervous conditions" that arise
in the text and reveal how each is entangled with colonialism.
In the novel "Nervous Conditions," the protagonist Nyasha suffers from bulimia nervosa, an eating disorder. Two other nervous conditions that arise in the text and reveal how each is with colonialism are anxiety and depression.
Anxiety is a feeling of worry, nervousness, or unease about something with an uncertain outcome. Anxiety is one of the other "nervous conditions" that arise in the text and reveal how it is with colonialism. Anxiety arises due to the and uncertain circumstances that the characters face as a result of colonialism. The anxiety of the characters is a reflection of the colonial experience they endure and their struggle to adapt to the cultural differences between their own and the colonial cultures.
The anxiety is entangled with colonialism because it arises from the uncertainties of colonialism and the struggles that the characters have to go through to adapt to it. Depression is another "nervous condition" that arises in the text and reveal how it is entangled with colonialism. Depression arises due to the oppressive and restrictive circumstances that the characters face as a result of colonialism. The characters feel powerless to change their situation and feel trapped in the colonial system. Depression is with colonialism because it arises from the circumstances that the characters face and the lack of power that they have to change their situation.
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