Describe how the binding of an agonist to a receptor is transduced to a physiological response through the activation of the IP3 second messenger pathway and how this can be modulated with drugs (34 marks)
(Please provide full details)

Answers

Answer 1

Agonist is defined as a drug or substance that binds to and activates the receptor of interest. When an agonist binds to a receptor, it initiates a conformational change that is transduced into a physiological response.

One way to transduce this response is through the IP3 second messenger pathway. The IP3 second messenger pathway is a signaling pathway that begins when an agonist binds to a receptor and triggers the activation of a G protein. The activated G protein then activates an enzyme called phospholipase C (PLC).

PLC cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into two second messengers  diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).The second messenger IP3 then diffuses through the cytoplasm and binds to its receptor on the endoplasmic reticulum (ER) membrane. This causes the release of calcium ions (Ca2+) from the ER into the cytoplasm.

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Related Questions

3. Appositional growth is growth in diameter. True or False? 4. The diameter of the medullary cavity stays the same throughout our life. True or False? 5. Type of bone growth; stops when the epiphyseal plate becomes the epiphyseal line. 6. Type of bone growth; known as bone modeling. 7. Hormones, stimulate growth of skeleton before puberty.. 8. Hormone produced in the pituitary gland, stimulates bone growth.. 9. Hormone produced in the thyroid gland, stimulates bone growth. 10. Hormones, stimulate osteoblasts. 11. Hormones, stimulate osteoclasts. 12. Hormones, promote conversion of epiphyseal plate into the epiphyseal line. 13. Hormones, trigger the growth spurt at puberty.. 14. Three organs: and 15. Bone cells, liquefy bone matrix and release calcium into the blood. 16. Bone cells, build bone matrix and deposit calcium into bone. 17. Bone cells, source of osteoblasts.. 18. Mature bone cells, maintain the health of osseous tissue. 19. In hypocalcemia, . 20. In hypercalcemia,.. 21. When osteoblasts are activated, Ca++ moves from 22. When osteoclasts are activated. Ca++ moves from 23. When osteoblasts are inhibited. Ca deposition 24. When osteoclasts are inhibited, Ca deposition_ 25. If we can absorb more Ca++ from the intestine, Ca blood levels will. 26. If we absorb less Ca++ from the intestine, Ca blood levels will 27. If kidneys can reabsorb more Ca++, Ca blood levels will 28. If kidneys can eliminate more Ca++, Ca blood levels will 29. Cells of osseous tissue, responsible for bone deposition_ 30. Cells of osseous tissue, responsible for bone resorption. 31. Osteoclasts are more active in what conditions? 32. Osteoblasts are more active in what conditions? activate vit. D and transform it into is released from the parathyroid gland, causing calcium to be released from bones. is released from the thyroid gland. to to (increases or decreases). (increases or decreases). (increase or decrease) (increase or decrease) (increase or decrease) (increase or decrease)

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Appositional growth is growth in diameter is a True statement. Appositional growth occurs when bone diameter grows wider or thicker during modeling.

The bone deposition occurs on the outer surface, and the resorption occurs on the inner surface of the bone. The diameter of the medullary cavity stays the same throughout our life.  The diameter of the medullary cavity is variable throughout our life. During bone growth, the diameter of the medullary cavity increases. Type of bone growth; stops when the epiphyseal plate becomes the epiphyseal line. Endochondral ossification is a form of bone growth that stops when the epiphyseal plate becomes the epiphyseal line. Type of bone growth; known as bone modeling.

Bone modeling is a type of bone growth. It involves the shaping of the bone as a result of the mechanical forces imposed on it. Hormones, stimulate the growth of the skeleton before puberty. Growth hormones stimulate the growth of the skeleton before puberty. Hormone produced in the pituitary gland, stimulates bone growth. The hormone produced in the pituitary gland that stimulates bone growth is somatotropin (STH). Hormone produced in the thyroid gland, stimulates bone growth. Thyroid hormones, such as thyroxine, stimulate bone growth. Hormones, stimulate osteoblasts. The hormone that stimulates osteoblasts is estrogen. Hormones, stimulate osteoclasts. Parathyroid hormones stimulate osteoclasts.

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Final answer:

The questions cover key concepts and facts about bone growth, modeling and resorption. They touch upon the roles of hormones, the function of different bone cells and the effects of calcium levels on the activity of these cells.

Explanation:

3. Appositional growth is growth in diameter. True. This type of growth occurs in the periosteum where new bone tissue is added to the surface.

4. The diameter of the medullary cavity stays the same throughout our life. False. It actually increases with age as bone marrow slowly gets replaced by fat in a process known as yellow marrow conversion.

5. The type of growth that stops when the epiphyseal plate becomes the epiphyseal line is known as longitudinal growth.

6. Bone modeling is the process that causes change in bone shape.

7. Growth hormone and thyroid hormone stimulate the growth of a skeleton before puberty.

8. Growth hormone, produced in the pituitary gland, stimulates bone growth.

9. Thyroid hormone, produced in the thyroid gland, also stimulates bone growth.

16. Osteoblasts are bone cells that build the bone matrix and deposit calcium into the bone.

17. Osteoprogenitor cells are the source of osteoblasts.

31. Osteoclasts are more active in conditions of low blood calcium levels, as they break down bone to release calcium.

32. Osteoblasts are more active in conditions of high blood calcium levels, as they use this calcium to build new bone tissue.

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what is the mechanism of extra cellular edema

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Extracellular edema occurs due to an imbalance between hydrostatic and oncotic pressures in the capillaries, resulting in fluid accumulation in the interstitial space.

Extracellular edema, also known as interstitial edema, occurs when fluid accumulates in the spaces between cells in the interstitial or extracellular space. This can be caused by various mechanisms and conditions.

The primary mechanism of extracellular edema is an imbalance between hydrostatic pressure and oncotic pressure in the capillaries. Normally, hydrostatic pressure within the capillaries pushes fluid out into the interstitial space, while oncotic pressure, mainly due to the presence of plasma proteins like albumin, pulls fluid back into the capillaries.

However, when there is an increase in hydrostatic pressure or a decrease in oncotic pressure, fluid accumulation in the interstitial space occurs.

Several factors can contribute to extracellular edema formation. Increased hydrostatic pressure can result from venous obstruction or increased capillary permeability, such as in inflammation or injury.

Reduced oncotic pressure can occur in conditions like liver disease, where there is decreased synthesis of plasma proteins. Lymphatic obstruction or dysfunction can also lead to extracellular edema since the lymphatic system plays a crucial role in draining excess fluid from the interstitial space.

The consequences of extracellular edema can be detrimental. The excess fluid accumulation increases the distance for nutrients and oxygen to diffuse to the cells, leading to tissue hypoxia. It can also impair the removal of waste products, further compromising tissue function.

Additionally, the swelling and increased pressure on surrounding structures can contribute to pain and impaired organ function.

Treatment of extracellular edema involves addressing the underlying cause, such as treating inflammation, improving venous or lymphatic flow, or managing conditions affecting plasma protein levels. Modalities like compression therapy, elevation, and diuretic medications may also be utilized to reduce fluid accumulation.

In conclusion, Understanding the underlying mechanisms and addressing the underlying causes are crucial in managing extracellular edema and minimizing its impact on tissue function.

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An increase in blood CO2 causes:
a decrease in H+ and therefore a drop in pH
a decrease in H+ and therefore an increase in pH
an increase in H+ and therefore a drop in pH
an increase in H+ and therefore an increase in pH

Answers

The correct option is C. H+ and therefore a drop in pH . An increase in blood CO2 causes an increase in H+ and therefore a drop in pH.

pH is a term used to indicate the acidity or basicity (alkalinity) of a solution. The pH scale ranges from 0 to 14, with 7 being neutral, less than 7 acidic, and greater than 7 alkaline. The pH of normal arterial blood ranges from 7.35 to 7.45. A decrease in pH is referred to as acidemia, whereas an increase in pH is referred to as alkalemia.

Respiration, specifically the exchange of gases, is the process by which CO2 is generated and excreted. The bicarbonate buffer system aids in the maintenance of blood pH. It's important to keep a healthy balance between CO2 and H+ ions in the blood. When there is an increase in blood CO2, H+ increases, and the pH falls due to the bicarbonate buffer system not being able to keep up with the excessive CO2. Hence, An increase in blood CO2 causes an increase in H+ and therefore a drop in pH.

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Interpret the results of the blood typing test. This person has_____blood No agglutination agglutination Anti-A Anti-B Anti-Rh Choose all that apply: Which receptors are found on helper T cells? O CD8 receptors O CD4 receptors O a piece of viral protein O T-cell receptors O an antigen from the microbe A virus is injected into a rabbit and the rabbit is allowed to make antibodies against the viral antigen. These antibodies are then removed from the rabbit plasma and injected into a human to combat an infection by the same virus. This would be an example of O innate immunity O artificially induced passive immunity O artificially induced active immunity O naturally acquired passive immunity, O naturally acquired active immunity Choose all that apply: Which of the following statements are true? O the primary response occurs during the first exposure to a pathogen O the secondary response is usually much more rapid than the primary response O during the primary response, IgG antibodies are most commonly formed O during the secondary response, IgG antibodies are more commonly formed O the primary response to a pathogen usually creates enough antibodies to destroy it Calculate Heart Rate. HR = b/min. Only count complete boxes. Do not count 1/2 boxes. You will need to round your answer. Do not include decimal points.

Answers

CD4 receptors are found on helper T cells. CD8 receptors are found on cytotoxic T cells.

This would be an example of:

Artificially induced passive immunity. This is because the antibodies obtained from the rabbit plasma are directly injected into the human to combat the infection, providing immediate protection without the human's immune system actively producing the antibodies.

The secondary response is usually much more rapid than the primary response.

During the primary response, IgG antibodies are not commonly formed. IgM antibodies are typically the first antibodies produced.

During the secondary response, IgG antibodies are more commonly formed.

The blood typing test results indicate that this person has no agglutination, which suggests that they have type O blood and do not have the A or B antigens present on their red blood cells. Additionally, there is no agglutination of the Rh factor, indicating that the person is Rh-negative.

The receptors found on helper T cells are CD4 receptors. These receptors play a crucial role in the immune response by recognizing antigens presented by antigen-presenting cells and activating the immune system.

The scenario described, where antibodies generated in a rabbit against a viral antigen are transferred to a human to combat an infection by the same virus, represents artificially induced passive immunity. The pre-formed antibodies provide immediate protection to the human, but the immune response is temporary since the transferred antibodies will eventually degrade.

The following statements are true:

The primary response occurs during the first exposure to a pathogen.

The secondary response is usually much more rapid and stronger than the primary response.

During the primary response, IgM antibodies are commonly formed.

During the secondary response, IgG antibodies are more commonly formed. The secondary response is characterized by the production of memory B cells, which can quickly differentiate into plasma cells and produce large amounts of IgG antibodies upon re-exposure to the same pathogen.

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3. What's the beef with vegan diets? Forty-two migraine sufferers participated in a randomized trial comparing two treatments: Dietary restrictions: low-fat vegan diet for 4 weeks followed by elimination and reintroduction of trigger foods for 12 weeks . Placebo supplement for 16 weeks (with no dietary changes) The participants were randomly assigned to treatments such that there were 21 participants per group. Participants kept a diary of headache pain on a 10-point scale during the 16-week study, which was used to compute the average amount of headache pain per participant. a. Draw a diagram for this experiment. Label the subjects, treatments, group sizes, and response variable. [3 marks] b. Were the subjects blind? Briefly explain. [1 mark] c. Participants were told that the placebo supplement contained omega-3 oils and vitamin E, which are known to be anti-inflammatory. However, the participants did not know that the concentrations were too low to have any clinical impact. Was this a good choice of placebo for this experiment? Explain why or why not. [2 marks] d. Suppose the dietary restriction group had significantly less headache pain than the placebo group. Explain why the two types of dietary restrictions applied ("vegan diet" and "elimination and reintroduction of trigger foods") are confounded in this experiment. [2 marks]

Answers

The placebo supplement was a poor choice for this experiment since the participants were given incorrect information about its contents. The two types of dietary restrictions, vegan diet and elimination and reintroduction of trigger foods, are confounded in this experiment because the group that followed the vegan diet also followed the elimination and reintroduction of trigger foods.

a. Diagram for the given experiment:

Subjects, treatments, group sizes, and response variable are as follows:

The subjects are the 42 migraine sufferers.The treatments are a low-fat vegan diet for 4 weeks, followed by the elimination and reintroduction of trigger foods for 12 weeks, and a placebo supplement for 16 weeks (with no dietary changes).There are 21 participants per group.The response variable is the average amount of headache pain per participant.

b. The subjects were not blind because one group was following a vegan diet, while the other group was taking a placebo supplement. This made the experiment an open-label randomized trial. Since there was no blinding, the results are more likely to be affected by placebo effects and/or the subjects' expectations of improvement.

c. The placebo supplement was a poor choice for this experiment since the participants were given incorrect information about its contents. Even if the placebo had the expected clinical impact, the results of the experiment would be biased because the participants were misinformed.

d. The two types of dietary restrictions, vegan diet and elimination and reintroduction of trigger foods, are confounded in this experiment because the group that followed the vegan diet also followed the elimination and reintroduction of trigger foods. As a result, it is impossible to determine which dietary restriction contributed more to the observed reduction in headache pain.

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The hypothalamus ________.
Group of answer choices
A. is the thermostat of the body because it regulates temperature in the preoptic area
B. can be stimulated by sensory information from other brain areas, changes in CSF composition, and chemical stimuli in blood
C. contains the mammillary bodies
D. produces 2 important hormones that are stored in the posterior pituitary gland
E. All of the above

Answers

The hypothalamus is the thermostat of the body because it regulates temperature in the preoptic area. The correct option is A.

The hypothalamus is a structure located beneath the thalamus and above the brainstem. It has numerous essential roles, including controlling appetite, regulating hormones, and controlling temperature.

The hypothalamus functions as the thermostat of the body because it regulates temperature in the preoptic area. It acts as a thermometer, sensing changes in the temperature of blood and relaying that information to the rest of the body.

Other brain areas, changes in cerebrospinal fluid (CSF) composition, and chemical stimuli in the blood can all stimulate the hypothalamus. In addition, the hypothalamus controls the pituitary gland, which is responsible for regulating various hormones in the body. The hypothalamus also produces two important hormones that are stored in the posterior pituitary gland: antidiuretic hormone (ADH) and oxytocin. Therefore, the correct option is A.

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Notice that in the alignment table, the data are arranged so each globin pair can be compared.

a. Notice that some cells in the table have dashed lines. Given the pairs that are being compared for these cells, what percent identity value is implied by the dashed lines?

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The percent identity value implied by the dashed lines given the pairs that are being compared for these cells in the alignment table is 75%

.When comparing the globin pairs in the alignment table, some cells are marked with dashed lines. The dashed lines indicate the percent identity value that is implied for the pairs that are being compared in these cells. If the pair has dashed lines, the percent identity value is 75 percent. A percent identity value of 75% is considered a weak match because the two globin sequences being compared have a 25% difference in their amino acid sequence.Therefore, the percent identity value implied by the dashed lines given the pairs that are being compared for these cells in the alignment table is 75%.

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Make a table listing all the components found in semen. For each component in semen, list the relative amounts, site of production and function,

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Here is a table listing some of the components found in semen, along with their relative amounts, site of production, and function:\

Please note that the relative amounts mentioned above are approximate and can vary from person to person.

Here is a table listing the major components found in semen, along with their relative amounts, site of production, and function:

Component Relative Amount Site of Production Function

Spermatozoa 2-5% Testes Fertilization of female gametes

Seminal Fluid 65-75% Seminal Vesicles, Prostate Gland, Bulbourethral Glands Provides nutrients and energy for spermatozoa, alkaline pH to neutralize acidic environment of the female reproductive tract

Prostaglandins < 1% Seminal Vesicles, Prostate Gland Stimulate uterine contractions and facilitate movement of spermatozoa through the female reproductive tract

Fructose 5-8 mM Seminal Vesicles Provides energy for spermatozoa

Citrate 50-150 mM Prostate Gland Provides energy for spermatozoa

Acid phosphatase < 1% Prostate Gland Breaks down proteins in the female reproductive tract to facilitate movement of spermatozoa

Zinc 3-4 mM Prostate Gland Essential for sperm formation and function

Fibrinolysin < 1% Seminal Vesicles Breaks down fibrin clots in the female reproductive tract to facilitate movement of spermatozoa

Enzymes (e.g. proteases, lipases) < 1% Prostate Gland, Seminal Vesicles  Facilitate breakdown of cervical mucus and other barriers in the female reproductive tract

Note that the relative amounts and specific functions of these components may vary somewhat depending on the individual and other factors.

Paul (blood type A. Rh y is enraged to Lira (blood type B. Rir), Given theit respective blood types. Which potential problem might the couple face in their future as a family. Which medical advice would you give the couple. (Telling them not to get married is not a valid answer)

Answers

The couple may face a potential problem regarding erythroblastosis fetalis in their future as a family due to the different blood types. This may lead to a condition in which the mother’s immune system attacks the baby’s blood cells because of incompatibility.

Therefore, it is important to give medical advice to the couple. They should get regular check-ups during pregnancy and ensure that the baby is healthy. The baby may require a blood transfusion after birth if the condition is severe. The couple should be informed about Rh factor incompatibility and the risk it poses to their future offspring.

They can undergo genetic counseling and testing to determine the risk of future pregnancies having Rh factor incompatibility. In some cases, preventive measures like RhoGAM injections may be prescribed to prevent erythroblastosis fetalis. The couple should consult their physician or a qualified genetic counselor for further advice.

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Explain how airway resistance, alveolar surface tension, and lung compliance affect pulmonary ventilation. (note: low compliance lungs are stiff and recoil strongly and high compliance lungs are loose and recoil poorly). What happens in a patient with emphysema?

Answers

Airway resistance, alveolar surface tension, and lung compliance are important factors that influence pulmonary ventilation, which refers to the movement of air into and out of the lungs.

1. Airway resistance: Airway resistance is the opposition to airflow within the respiratory system. It is primarily determined by the diameter of the airways. Narrowing or constriction of the airways increases resistance, making it harder for air to flow in and out of the lungs. Conversely, dilation or relaxation of the airways decreases resistance, facilitating airflow. Higher airway resistance can impede ventilation and require more effort to breathe.

2. Alveolar surface tension: Alveolar surface tension is the force present at the air-liquid interface within the alveoli of the lungs. It is primarily due to the surface tension of the fluid lining the alveoli. Surface tension tends to collapse the alveoli, making it more difficult to inflate them during inspiration. However, the presence of surfactant, a substance produced by specialized cells in the alveoli, reduces surface tension and prevents alveolar collapse. Reduced surface tension allows for easier expansion of the alveoli during inspiration and enhances pulmonary ventilation.

3. Lung compliance: Lung compliance refers to the distensibility or elasticity of the lung tissue. It represents how easily the lungs can expand or recoil during breathing. High lung compliance means that the lungs can stretch and expand readily, requiring less effort to fill with air during inspiration. Low lung compliance indicates that the lung tissue is stiff and resistant to expansion, resulting in increased effort required to ventilate the lungs.

In patients with emphysema, the lung tissue is characterized by the destruction of alveolar walls, leading to the loss of elastic recoil and reduced lung compliance. This results in lungs with high compliance, meaning they are loose and recoil poorly. Due to the loss of alveolar structure and elasticity, the small airways collapse during expiration, causing air trapping within the lungs.

This trapped air leads to increased lung volumes, known as hyperinflation. Consequently, in emphysema, there is increased airway resistance due to narrowed and obstructed airways, impaired alveolar surface tension regulation, and decreased lung compliance. These factors collectively contribute to reduced pulmonary ventilation and difficulties in exhaling air efficiently. Shortness of breath and labored breathing are common symptoms experienced by individuals with emphysema.

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At the primary consumer level, the available energy is measured to be 1000 kilocalories (kcal). what will be the approximate available energy for a tertiary consumer level?

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The approximate available energy for a tertiary consumer level would be around 100 kilocalories (kcal).

At the primary consumer level, the available energy is measured to be 1000 kilocalories (kcal). The approximate available energy for a tertiary consumer level can be estimated by considering the energy transfer efficiency between trophic levels. On average, the energy transfer efficiency is about 10% from one trophic level to the next.

To calculate the approximate available energy for a tertiary consumer level, we can multiply the available energy at the previous trophic level (primary consumer level) by the energy transfer efficiency.

In this case, the available energy at the tertiary consumer level can be estimated as follows:

Available energy at tertiary consumer level = Available energy at primary consumer level x Energy transfer efficiency

Available energy at tertiary consumer level = 1000 kcal x 0.10

Available energy at tertiary consumer level ≈ 100 kcal

Therefore, the approximate available energy for a tertiary consumer level would be around 100 kilocalories (kcal).

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a. Please select one answer from the parenthesis to complete the sentence.
When a photoreceptor is in the dark, the the on-center bipolar cells will (depolarize or hyperpolarize) , which will lead to (increase or decrease) firing in the on-center ganglion cell.
When a photoreceptor is in the dark, the off-center bipolar cell will (depolarize or hyperpolarize), which will lead to (increase or decrease) firing in the off-center ganglion cell.

Answers

When a photoreceptor is in the dark, the on-center bipolar cells will hyperpolarize, which will lead to a decrease in firing in the on-center ganglion cell. When a photoreceptor is in the dark, the off-center bipolar cell will depolarize, which will lead to an increase in firing in the off-center ganglion cell.

In the dark, photoreceptors are not stimulated by light. When a photoreceptor is in the dark, the on-center bipolar cells, which receive input from the photoreceptor, will hyperpolarize. Hyperpolarization means that the bipolar cell's membrane potential becomes more negative, reducing its activity. This hyperpolarization is due to the inhibitory neurotransmitter released by the photoreceptor, which decreases the release of excitatory neurotransmitters onto the bipolar cell. As a result, the on-center ganglion cell, which receives input from the bipolar cell, will also have a decrease in firing rate.

On the other hand, the off-center bipolar cell, which also receives input from the photoreceptor, will depolarize in the dark. Depolarization means that the bipolar cell's membrane potential becomes more positive, increasing its activity. This depolarization is due to the lack of inhibitory neurotransmitter released by the photoreceptor onto the off-center bipolar cell. Consequently, the off-center ganglion cell, which receives input from the depolarized bipolar cell, will experience an increase in firing rate.

Overall, when a photoreceptor is in the dark, the signaling pathway involving on-center bipolar cells and on-center ganglion cells is inhibitory, leading to a decrease in firing. In contrast, the pathway involving off-center bipolar cells and off-center ganglion cells is excitatory, resulting in an increase in firing.

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For the situation in #1B, what happens in each of the following parameters? (This question is NOT a MC question, but parts a-d. For example, in part a, will cardioinhibitory center or cardioacceleratory center be stimulated? Highlight the correct answer in color. Same for b through d.)
a.Cardioinhibitory center OR cardioaccelatory center is stimulated
b.Increase OR decrease in cardiac output
c.Increase OR decrease respiratory rate
d.More OR less oxygen getting to tissues

Answers

For the situation in #1B, Cardioacceleratory Center is stimulated, and the cardiac output increases. The answer is (C).

There will also be an increase in the respiratory rate, resulting in more oxygen getting to the tissues. A cardioacceleratory center stimulates the heart to beat more quickly, resulting in an increase in heart rate and cardiac output. On the other hand, a cardioinhibitory center slows the heart rate by inhibiting the cardiovascular center, decreasing heart rate and cardiac output.

The Cardioacceleratory center will be stimulated in situation #1B. Therefore, the answer for part a is cardioacceleratory center is stimulated. There will be an increase in the cardiac output, so the answer for part b is an Increase. The answer for part c is Increase because the respiratory rate increases. There will be more oxygen getting to tissues in this case, so the answer for part d is more oxygen getting to tissues.

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Lymphocytes that attack body cells infected with viruses are
Group of answer choices
a. plasma cells.
b. suppressor T cells.
c. B lymphocytes.
d. cytotoxic T cells.
e. helper T cells.

Answers

Lymphocytes that specifically target and attack body cells infected with viruses are called D. cytotoxic T cells,

Cytotoxic T cells, also known as killer T cells, are a type of white blood cell that plays a crucial role in the immune response against viral infections. These cells are part of the adaptive immune system and are responsible for recognizing and eliminating virus-infected cells.

When a virus infects a body cell, it presents small fragments of viral proteins, known as antigens, on its surface. Cytotoxic T cells have receptor molecules on their surface called T cell receptors (TCRs) that can recognize these viral antigens. When a cytotoxic T cell encounters a virus-infected cell displaying the specific viral antigen it recognizes, the TCR binds to the antigen, activating the cytotoxic T cell.

Once activated, cytotoxic T cells release toxic substances, such as perforin and granzymes, which can penetrate the infected cell's membrane and induce apoptosis (cell death). This process helps to eliminate the infected cell and stop the spread of the virus within the body.

In summary, cytotoxic T cells are lymphocytes specialized in targeting and destroying body cells infected with viruses. They play a vital role in the immune response against viral infections. Therefore, Option D is correct.

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Name
two accessory organs of digestive system that come in direct
contact of food

Answers

Two accessory organs of the digestive system that come in direct contact with food are the salivary glands and the pancreas.

Salivary Glands: The salivary glands, including the parotid, sublingual, and submandibular glands, produce saliva. Saliva contains enzymes such as amylase that begin the digestion of carbohydrates in the mouth. When we chew food, the salivary glands release saliva, which moistens the food, making it easier to swallow and initiating the breakdown of starches into simpler sugars.

Pancreas: The pancreas is a glandular organ located behind the stomach. It has both endocrine and exocrine functions. The exocrine portion of the pancreas secretes digestive enzymes, including pancreatic amylase, lipase, and proteases, into the small intestine. These enzymes are crucial for the digestion of carbohydrates, fats, and proteins. The pancreas also produces sodium bicarbonate, which neutralizes the acidic chyme from the stomach, creating a more optimal pH for the digestive enzymes to function effectively.

Both the salivary glands and the pancreas contribute to the breakdown of food by secreting enzymes that aid in the digestion process.

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Between which fingers should the thread be held for a square knot? a. Thumb and ring finger b. Index finger and thumb c. Index and middle finger d. Thumb and middle finger e. it does not matter which fingers are used

Answers

To tie a square knot, the thread should be held between the index finger and the thumb. The correct answer is b. Index finger and thumb.

A square knot is a type of knot used to tie two ropes of equal diameter or thickness. It is also referred to as a reef knot or Hercules knot. A square knot is formed by crossing the two ends of the rope, tying an overhand knot, and then tying another overhand knot in the opposite direction. When tied correctly, the square knot will not slip or loosen.Below are the instructions on how to tie a square knot:Hold the two ends of the rope in each hand.

Cross the right end over the left end of the rope.Bring the right end back and under the left end of the rope.Tie an overhand knot by passing the right end of the rope over the left end, then under and back through the loop formed. Bring the left end over the right end of the rope.Tie another overhand knot by passing the left end of the rope over the right end, then under and back through the loop formed.

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Please select the word from the list that best fits the definition
Land with different territories under a single rule

Answers

Answer:

The word that best fits the definition of "land with different territories under a single rule" is "empire". An empire is a sovereign state consisting of multiple territories or regions, often spanning across different continents and cultures, all governed by a single ruler or government.

In quadrupedal animals, two sets of anatomical terms can be used
almost interchangeably to label ventral to
anterior. What are these two sets of anatomical terms and
what are they referenced to?

Answers

In quadrupedal animals, two sets of anatomical terms can be used almost interchangeably to label ventral to anterior. These two sets of anatomical terms and what they are referenced to are:

1. Ventral and anterior:The term ventral is used to describe the belly side or underside of the body. The term anterior is used to describe the front end of the animal's body. Ventral and anterior are two sets of anatomical terms used almost interchangeably to label ventral to anterior.

2. Caudal and rostral:The term caudal is used to describe the tail end of the body, while rostral is used to describe the front end of the head. Caudal and rostral are two sets of anatomical terms used almost interchangeably to label ventral to anterior.

3. Animals are organisms that are living things that are not plants. These organisms include birds, mammals, fish, and reptiles, among others. In quadrupedal animals, two sets of anatomical terms can be used almost interchangeably to label ventral to anterior, including ventral and anterior, and caudal and rostral.

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1. Which buffer system seems more effective, the HCO3 system or the H2PO4 system? WHY?? 2. What is the H+ concentration (not pH ) of normal blood? Refer to lab 8.4 in the manual. 3. Both ammonia and phosphates can serve as urinary buffers. Why bother to buffer urine, since its going to be eliminated from the body?

Answers

1. HCO3 buffer system > H2PO4 system for pH balance.

2. Normal blood: H+ concentration ≈ 40 nM.

3. Buffering urine prevents damage, maintains pH. Ammonia, phosphates buffer.

1. The effectiveness of a buffer system depends on several factors, including the pKa of the buffering components and their concentrations. However, in general, the bicarbonate (HCO3) buffer system is considered more effective than the dihydrogen phosphate (H2PO4) buffer system in maintaining pH homeostasis in the body.

The HCO3 buffer system is a major extracellular buffer system in the body, playing a crucial role in regulating the pH of blood and other bodily fluids. It consists of the weak acid bicarbonate (HCO3-) and its conjugate base, carbonic acid (H2CO3), which is formed by the hydration of carbon dioxide (CO2) in the presence of the enzyme carbonic anhydrase.

The HCO3 buffer system is particularly effective in buffering changes in pH caused by the production of acidic or basic substances in the body. It can effectively regulate blood pH in the physiological range (around 7.35-7.45) by either accepting excess hydrogen ions (H+) when the pH is too low or releasing hydrogen ions when the pH is too high. This buffer system is also linked to the respiratory system, where the regulation of CO2 levels in the lungs helps maintain the balance of carbonic acid and bicarbonate in the blood.

On the other hand, the H2PO4 buffer system is primarily found in intracellular fluids, such as within cells. While it does contribute to pH regulation in the body, it is generally less effective than the HCO3 buffer system. The H2PO4 buffer system has a lower buffering capacity and a pKa closer to the physiological pH, making it less efficient in maintaining pH stability.

2. The concentration of hydrogen ions (H+) in normal blood is typically around 40 nanomoles per liter (nM). This value can vary slightly depending on the laboratory and the specific measurement technique used. It's important to note that the pH of normal blood is around 7.35-7.45, which corresponds to a slightly alkaline environment due to the presence of the bicarbonate buffer system.

3. Even though urine is ultimately eliminated from the body, buffering urine is essential for maintaining proper pH balance and minimizing damage to the urinary tract. The process of urine formation involves the excretion of various waste products, including excess hydrogen ions (H+) and ammonium ions (NH4+).

Ammonia (NH3) can be converted to ammonium (NH4+) in the kidneys, and it serves as a urinary buffer by accepting excess hydrogen ions. Similarly, phosphates can act as urinary buffers by accepting or donating hydrogen ions to help regulate the pH of urine.

Buffering urine is important because acidic or alkaline urine can cause irritation, inflammation, and damage to the urinary tract. It can lead to conditions like urinary tract infections, kidney stones, and other urinary disorders. By maintaining the pH within an optimal range (typically around 4.5-8), urinary buffers help prevent these harmful effects and promote the proper functioning of the urinary system.

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Q3. Answers Your Question with the help of analyzing and understanding skills using Convention ,Guidelines and
General coding guidelines with the help for Indexes and tabular list. And Write the explanation/rationale of each answers
that you agree upon either mentioning true or false. (Total Marks 6+6 Marks)
a. If a patient has a condition coded from Chapter 15, it will be first-listed.
b. For the patient’s first pre-natal visit, a trimester is assigned and does not change during future encounters.
c. If the clinician documents the patient is in their 16th week of the pregnancy, the patient is in their 1st trimester.
d. It is acceptable to use codes from category Z34, Encounter for supervision of normal pregnancy, with Chapter 15
codes.
e. To code live born infant including place of birth and type of delivery, codes from Chapter 15 are used.
f. For routine prenatal outpatient visits for patients with high-risk pregnancies, a code from category O09,
Supervision of high-risk pregnancy, should be used as the first-listed diagnosis.

Answers

Convention, guidelines and general coding guidelines with the help for indexes and tabular list aids the analysis and understanding skills to answer the following questions

The explanation/rationale for each answers are provided below:a. False: Conditions from Chapter 15 cannot be coded as the first-listed diagnosis unless they meet certain criteria.b. False: The trimester changes with each subsequent prenatal visit and may need to be updated accordingly.c. True: The first trimester of pregnancy is defined as up to and including 13 weeks and 6 days of gestation, so the 16th week of pregnancy falls within the first trimester.

d. True: Category Z34 codes can be used along with Chapter 15 codes when appropriate.e. False: Codes from Chapter 16, which is dedicated to perinatal conditions, should be used to code live born infants and related information.f. False: For routine prenatal outpatient visits for patients with high-risk pregnancies, a code from category O09 should be assigned as a secondary diagnosis, not as the first-listed diagnosis. The primary diagnosis should reflect the reason for the visit.

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s psoriasis induced by streptococcal superantigens and maintained by m-protein-specific t cells that cross-react with keratin?

Answers

Psoriasis induced by streptococcal superantigens and maintained by M-protein-specific T cells that cross-react with keratin is a hypothesis or theory. The etiology of psoriasis is not completely understood, but it is believed to be caused by a combination of genetic, environmental, and immunologic factors.

What is psoriasis?

Psoriasis is a chronic, inflammatory, immune-mediated skin disorder that affects roughly 2-3% of the world's population. It is characterized by erythematous, scaly plaques, which can cause significant morbidity and impair quality of life. Psoriasis has a variety of clinical phenotypes, with the most common being plaque psoriasis.The psoriasis is a multifactorial disease with complex etiology. Genetic, environmental, and immunologic factors are thought to contribute to the pathogenesis of this disorder. Streptococcal superantigens are thought to play a role in the pathogenesis of psoriasis. Superantigens are bacterial toxins that stimulate large numbers of T cells. The cross-reactivity of M-protein-specific T cells with keratin is another proposed mechanism. It is believed that these T cells, which are stimulated by streptococcal superantigens, may cross-react with keratin in the skin, resulting in inflammation and the formation of psoriatic plaques.

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What does compliance refer to? a. How readily the lungs rebound after having stretched. b. How much effort is required to stretch or distend the lungs c. How thick is the air entering the lungs

Answers

Compliance refers B. how much effort is required to stretch or distend the lungs.

It is the measure of lung elasticity that determines how much effort is required to inflate the lungs. The lungs must be able to expand and contract easily, which is an important factor for breathing. Compliance is defined as the change in lung volume per unit change in transpulmonary pressure. There are several factors that influence lung compliance. The most important of these is the presence of surfactant.

Surfactant is a mixture of lipids and proteins that is produced by alveolar cells. It decreases surface tension and helps to keep the alveoli open. Other factors that influence lung compliance include age, the presence of lung disease, and the elasticity of the chest wall. Compliance can be measured by several methods, including the pressure-volume curve and the forced expiratory volume test. So therefore the correct answer is B. how much effort is required to stretch or distend the lungs.

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Why does the skin of your mother's fingers shrink when she washes clothes for a long

time?

a. What is responsible for these changes? Explain the process in brief.

Answers

The skin of your mother's fingers shrinks when she washes clothes for a long time due to prolonged exposure to water. This exposure disrupts the natural balance of moisture in the skin, leading to the shrinkage.

1. When your mother washes clothes for a long time, her fingers come into contact with water continuously.

2. Water is a natural solvent and can dissolve substances, including the protective oils and moisture present on the skin.

3. The outermost layer of the skin, called the stratum corneum, acts as a barrier to prevent excessive water loss and protect against external factors.

4. Prolonged exposure to water can cause the stratum corneum to become saturated and swell.

5. As the stratum corneum absorbs water, it expands, which can lead to the appearance of wrinkled or shriveled skin.

6. Additionally, water exposure can wash away the natural oils that help keep the skin hydrated and supple.

7. Without these oils, the skin's natural moisture balance is disrupted, causing it to dry out and shrink.

8. Continuous wetting and drying cycles can further aggravate the skin's condition, leading to more pronounced shrinkage and roughness.

9. It's important to note that different individuals may experience varying degrees of skin shrinkage depending on their skin type, overall skin health, and environmental factors.

In summary, the prolonged exposure to water during clothes washing disrupts the skin's moisture balance, leading to the shrinkage and wrinkling of your mother's fingers.

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Without surfactant... ◯ There is no immune function in the alveoli ◯ Debris is not removed from the alveoli ◯ Gases would exchange in the alveoli ◯ Alveoli collapse with every exhalation

Answers

Without surfactants, alveoli would collapse with every exhalation.

Surfactant is a complex substance produced in the lungs. Surfactant lowers the surface tension of the alveoli walls and reduces the forces that are required to keep the alveoli open. It is responsible for keeping the lungs inflated and reducing the effort required to breathe by preventing the collapse of the air sacs during exhalation. In the absence of surfactant, alveoli would collapse with every exhalation.

When we breathe, the air we inhale fills our lungs. Our lungs are composed of tiny sacs called alveoli, which are responsible for exchanging gases between the air we breathe and our bloodstream. These alveoli are lined with a thin film of fluid that creates surface tension, which makes it difficult for the alveoli to expand and contract. This surface tension makes it harder to breathe, and without surfactant, the alveoli would collapse with every exhalation. The lack of surfactant would lead to lung diseases such as acute respiratory distress syndrome (ARDS) in which the alveoli can collapse and become stiffened, making it difficult to breathe.

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What are two things that should be done to make sure flexibility
measurements are valid? Explain why they help produce valid
measurements.

Answers

Two things that should be done to make sure flexibility measurements are valid are Consistency in the measurement method: It is important to ensure that the measurement method is consistent to avoid errors.

Using reliable equipment: Reliable equipment must be used to measure the range of motion.

1. It is important to ensure that the measurement method is consistent to avoid errors. Any changes in the technique can lead to differences in the results obtained.

2. It is important to maintain the same speed, direction, and joint position each time the measurement is taken to ensure consistency.

3. Using reliable equipment is necessary to measure the range of motion accurately. Any inaccuracies in the equipment will lead to incorrect measurements. Therefore, measuring tapes should be calibrated, and goniometers should be checked for accuracy to ensure valid measurements.

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your subject's TLC is 5.9, their IRV is 1.8, Their IC is 2.4,
and their RV is 1.2. What is their FRC?

Answers

TLC is 5.9, their IRV is 1.8, Their IC is 2.4, and their RV is 1.2.  then the subject's FRC is 0.2 L

The subject's TLC is 5.9, their IRV is 1.8, their IC is 2.4, and their RV is 1.2.

We have to determine their FRC.

To calculate the FRC, we need to use the following formula:

FRC = RV + ERV

Where,ERV = FRC - RV

ERV is the expiratory reserve volume.

The residual volume is the air that remains in the lungs after a forced expiration.

ERV + RV = Functional Residual Capacity (FRC)

Let's solve the problem.

TLC = RV + IRV + TV + ERV + IC5.9

= 1.2 + 1.8 + TV + ERV + 2.4TV + ERV

= 5.9 - 1.2 - 1.8 - 2.4TV + ERV

= 0.5

The question is asking for FRC, which is the sum of ERV and RV:

ERV = FRC - RVERV + RV = FRCERV + 1.2

= FRCERV = FRC - 1.2

Now, substitute this into the earlier equation:

TV + ERV = 0.5TV + FRC - 1.2

= 0.5TV = 0.7 + 1.2 - FRC-TV

= 1.9 - FRC

Now, substitute this into the equation

FRC = RV + ERV:ERV = FRC - RVFRC - RV

= ERFRC - 1.2 - ERFRC - RV

= 1.2RV = FRC - 1.2

Now, substitute this into the equation

TV = 1.9 - FRC:TV + FRC - 1.2

= 0.5TV = 0.7 + 1.2 - FRC1.9 - FRC + FRC - 1.2

= 0.5TV

= 0.7 + 1.2 - FRC0.7

= 0.5FRC

= 0.2FRC

= 0.2 L

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Describe the process of spermatogenesis and explain the difference between spermatogenesis and spermiogenesis. What role do the Sertoli cells play in spermatogenesis and how do they interact with Leydig cells to support sperm production in the testis.
Male Reproduction question -15 marks

Answers

Spermatogenesis is the process of sperm cell development, while spermiogenesis is the process of sperm cell maturation. Sertoli cells play a crucial role in spermatogenesis by providing physical and nutritional support to developing sperm cells, while Leydig cells produce testosterone, which is essential for sperm production.

Spermatogenesis is the complex process through which spermatogonial stem cells in the testes undergo mitotic division and differentiation to form mature sperm cells. It consists of three main phases: proliferation, meiosis, and differentiation. During proliferation, spermatogonial stem cells divide to produce more stem cells and spermatogonia. In the subsequent meiotic phase, spermatocytes undergo two rounds of cell division to form haploid spermatids. Finally, during differentiation, spermatids undergo morphological changes to develop into mature sperm cells.

Spermiogenesis, on the other hand, is the final stage of spermatogenesis and involves the maturation of spermatids into fully functional sperm cells. It includes the formation of the acrosome, development of the flagellum, and the shedding of excess cytoplasm. The resulting sperm cells are now capable of fertilizing an egg.

Sertoli cells, also known as nurse cells, are a type of supporting cell found within the seminiferous tubules of the testes. They play a vital role in spermatogenesis by providing physical and nutritional support to developing sperm cells. Sertoli cells create a microenvironment within the seminiferous tubules that is essential for spermatogenesis to occur. They supply nutrients, hormones, and growth factors necessary for sperm cell development. Sertoli cells also help in the removal of excess cytoplasm during spermiogenesis.

Leydig cells, located in the interstitial tissue surrounding the seminiferous tubules, produce testosterone in response to luteinizing hormone (LH) stimulation. Testosterone is a key hormone required for spermatogenesis. It promotes the proliferation and differentiation of spermatogonial stem cells and influences the development of secondary sexual characteristics. The interaction between Sertoli cells and Leydig cells is crucial for the regulation of spermatogenesis. Sertoli cells create a favorable environment for the development of sperm cells, while Leydig cells provide the necessary hormonal support.

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Match the following structures with the correct function: sarcolemma ______
sarcoplasmic reticulum ________
T-tubules _________
sarcomere ________
dystrophin _______
myoglobin ________

Answers

Sarcolemma: Muscle fiber membrane for electrical conduction.

Sarcoplasmic reticulum: Stores and releases calcium for contraction.

T-tubules: Transmit electrical impulses for coordination.

Sarcomere: Basic contractile unit of muscle.

Dystrophin: Maintains muscle fiber integrity.

Myoglobin: Stores and transports oxygen for energy.

sarcolemma - The sarcolemma is the plasma membrane of a muscle fiber. It serves as a protective barrier and plays a crucial role in muscle contraction by conducting electrical impulses that initiate muscle action potentials.

sarcoplasmic reticulum - The sarcoplasmic reticulum is a specialized type of endoplasmic reticulum found in muscle cells. Its primary function is to store and release calcium ions (Ca2+) during muscle contraction and relaxation. The release of calcium ions from the sarcoplasmic reticulum triggers muscle contraction.

T-tubules - T-tubules, also known as transverse tubules, are invaginations of the sarcolemma that extend deep into the muscle fiber. They allow for the rapid transmission of electrical impulses (action potentials) from the sarcolemma to the interior of the muscle fiber. T-tubules play a crucial role in coordinating the contraction of muscle fibers.

sarcomere - A sarcomere is the basic contractile unit of skeletal muscle. It is defined as the segment between two Z-discs and consists of overlapping actin and myosin filaments. Sarcomeres are responsible for muscle contraction and are organized in a repeating pattern along the length of muscle fibers.

dystrophin - Dystrophin is a protein found in muscle cells that plays a critical role in maintaining the structural integrity of muscle fibers. It connects the cytoskeleton of muscle cells to the sarcolemma, providing stability during muscle contraction. Mutations in the dystrophin gene can lead to muscular dystrophy, a group of inherited muscle diseases.

myoglobin - Myoglobin is a protein found in muscle cells that is responsible for storing and transporting oxygen within muscle fibers. It has a higher affinity for oxygen than hemoglobin, allowing it to efficiently extract oxygen from the bloodstream and deliver it to the mitochondria within muscle cells for energy production. Myoglobin gives muscles their reddish-brown color.

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Find three examples from current events that promote indigenous
knowledge of the landscape applied to modern environmental
problems

Answers

Three examples from current events that promote indigenous knowledge of the landscape applied to modern environmental problems are:

Indigenous-led conservation initiatives: Many indigenous communities are taking the lead in environmental conservation efforts, drawing on their traditional knowledge of the land to protect and restore ecosystems. Indigenous land management practices: Indigenous communities around the world are showcasing sustainable land management practices that prioritize ecological balance and resilience. For instance, the use of controlled burns by indigenous people in Australia has been recognized as an effective method to prevent wildfires and support biodiversity. Collaborative resource management partnerships: Governments and organizations are increasingly recognizing the value of incorporating indigenous knowledge into decision-making processes.

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if Tertilization occurs, the corpus A. Produces estrogen. B. Produces progesterone. C. Produces inhibin D. All of the above E. Only two of the above. 493 points Breast milk production is stimulated by: A. FSH. B. Oxytocin. C.DHT. D. Relaxin. E. Prolactin. 50 3 points For which of the following STD's is there no cure? A. Syphilis. B. Gonorrhea. C. Trichomoniasis. D. Herpes Simplex 11 F.Chlamydia

Answers

If fertilization occurs, the corpus luteum produces progesterone, estrogen, and inhibin. The correct option is D. All of the above. In the female reproductive system, the corpus luteum is a gland that is formed in the ovary after ovulation.

Breast milk production is stimulated by the hormone prolactin. Therefore, the correct option is E. Prolactin. Breast milk production, also known as lactation, is stimulated by hormones. Prolactin is the primary hormone responsible for this process. Prolactin is generated by the anterior pituitary gland in response to an infant's suckling or suckling sounds.

There is no cure for Herpes Simplex 11. Therefore, the correct option is D. Herpes Simplex 11. Sexually transmitted diseases are caused by bacteria, viruses, or other pathogens that are spread via sexual contact. While some STDs can be cured with antibiotics or other medications, there are others for which there is no cure.

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