Osteocytes, osteoblasts, and osteoclasts are bone cell that work together in bone formation, bone maintenance, and bone remodeling. Below are the functions of each cell:
Functions of Osteocytes: They are mature bone cells that help maintain the bone matrix by regulating mineral exchange with extracellular fluid.
Functions of Osteoblasts: They are bone-forming cells responsible for the synthesis and secretion of collagen fibers and other organic components of the bone matrix.
Functions of Osteoclasts: They are multinucleated cells responsible for the breakdown of bone tissues and minerals. They are involved in bone resorption.
Osteocytes, osteoblasts, and osteoclasts work together in bone remodeling. Bone remodeling is a process that involves the removal of old bone tissues and the formation of new bones. This process occurs in response to mechanical stress, bone growth, and mineral homeostasis.Bone resorption is the process by which osteoclasts break down old or damaged bone tissues. During bone resorption, osteoclasts secrete enzymes that dissolve the organic and inorganic components of the bone matrix.
The dissolved minerals are released into the bloodstream for reutilization.Bone deposition is the process by which osteoblasts synthesize and secrete new bone tissues. During bone deposition, osteoblasts produce collagen fibers and other organic components of the bone matrix. They also promote the deposition of calcium and other minerals in the bone matrix.Bone remodeling is the process by which old bone tissues are removed and new bone tissues are deposited. It is essential for bone maintenance and bone growth. The process involves the coordination of osteocytes, osteoblasts, and osteoclasts.
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Question Two Answer both parts, (i) and (ii). (i) Describe how isolated tissue experiments can be used to detect the following type of receptor-ligand behaviour: agonism, partial agonism, antagonism, irreversible antagonism 110 Marks) (ii) Outline a structure-activity profile for the fluoroquinoline group of antibacterial agents. Your answer should also describe the attractions of incorporation of fluorine as a substituent in the molecular structures of APIs/prospective APIs. [10 Marks)
The isolated tissue experiments have been used to detect the following receptor-ligand behavior. Here’s how: Isolated Tissue experiments and Agonism.
Agonism is detected through measuring the contraction of an isolated tissue sample when the sample is exposed to a particular receptor ligand. Here, the receptor agonist's concentration and the agonist's potency is increased until the tissue reaches maximum contraction. Isolated Tissue experiments and Partial AgonismPartial agonism is detected in a similar way to agonism. Here the isolated tissue samples are treated with two types of drugs. The tissue sample’s response is then measured in terms of their maximum possible response, as well as the response of the tissue sample’s agonist.
Antagonism is detected by exposing an isolated tissue sample to an agonist and then measuring the antagonists’ ability to compete with agonist’s effects. The tissue’s response to the agonist is then compared to the response elicited by the agonist in the presence of the antagonist. Isolated Tissue experiments and Irreversible Antagonism An irreversible antagonist is detected by allowing the antagonist to act on a tissue sample for an extended period of time, after which the agonist is introduced. If the agonist fails to elicit the expected response, then the presence of an irreversible antagonist can be inferred.
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Mr Lambert consults you about pain in the sides; during the visit, you take note of the following signs: fatigue, discouragement - fever and shivers – irregular stools – dark urine - nausea, vomiting – bitter mouth, coated tongue – bad breath
Choose the right energetic diagnosis
A Deficient yang of the kidney
B Blocked Qi of the liver
C Hyperactive yang of the liver
D Humidity-heat liver-gall bladder
The correct energetic diagnosis based on the given signs including fatigue and discouragement, fever and shivers, irregular stools, dark urine, nausea and vomiting, bitter mouth, coated tongue, and bad breath is the Humidity-heat liver-gall bladder. The answer is (D).
The liver and gallbladder regulate Qi and are responsible for the smooth flow of emotions in the body. When the liver fails to regulate the emotional states, it can cause it to stagnate and accumulate, resulting in a blockage. Hence, the blocked Qi of the liver can be seen as irritability, depression, and general feelings of frustration.
The problem described here involves fever and shivers, nausea and vomiting, dark urine, bitter mouth, coated tongue, and bad breath. This suggests a condition of humidity-heat affecting the liver-gall bladder. This is particularly true when accompanied by fatigue and discouragement. Therefore, the correct energetic diagnosis is D. Humidity-heat liver-gall bladder.
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The structure that receives the secondary oocyte after ovulation is the: a. ovarian ligament b. Graafian follicle c. uterine tube d. ovarian epithelium
The structure that receives the secondary oocyte after ovulation is the uterine tube (c).
Ovulation is the process in which the female reproductive system releases an egg or an ovum. The egg is released by the ovary, and then travels down the fallopian tube to reach the uterus. During this journey, the egg may or may not get fertilized by the sperm. If it is not fertilized, then it will disintegrate and the process of menstruation will take place. The secondary oocyte is released from the ovary at the time of ovulation, which is the release of an egg from the ovary. The secondary oocyte is then picked up by the fimbriae, which are finger-like projections located at the end of the fallopian tubes.
The fimbriae create a gentle suction that pulls the egg into the fallopian tube.Once the secondary oocyte enters the fallopian tube, it begins to travel towards the uterus, aided by the cilia lining the walls of the tube. It is in the fallopian tube where fertilization occurs, if a sperm is present. If fertilization occurs, the fertilized egg, now called a zygote, will continue its journey towards the uterus, where it will implant itself in the uterine lining. If fertilization does not occur, the secondary oocyte will disintegrate and be expelled during menstruation.
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How is the lagging strand built during DNA replication?
Explanation:
The leading strand is synthesized by adding nucleotides to the 3' end of the growing strand, and the lagging strand is synthesized by adding nucleotides to the 5' end. The lagging strand is synthesized continuously, whereas the leading strand is synthesized in short fragments that are ultimately stitched together.
USLIIS 10 point Montal contrasting is the strategy for setting goals which includes both Vividly imagining the future outcome you would like to achieve and all the good things that can accompany it . Focusing on all of the obstacles that could potentially got in the way of accomplishing their goals O True
O False
The statement "USLIIS 10 point Montal contrasting is the strategy for setting goals which includes both Vividly imagining the future outcome you would like to achieve and all the good things that can accompany it . Focusing on all of the obstacles that could potentially got in the way of accomplishing their goals" is false. SO the given statement is false
The USLIIS 10 point system is a goal-setting system. It helps you in defining your objectives and objectives that you want to attain with regards to your profession. It can be used in both personal and professional situations to help you reach your goals. The system is made up of ten key elements, each of which is designed to assist you in defining your objectives and making progress toward them. Contrasting is a technique that was created by the German philosopher Oettingen. It's a two-step procedure for reaching one's goals.
People who want to achieve a goal use this strategy by first visualizing the positive future outcome they want to attain, and then imagining all the obstacles that could get in the way of achieving that goal. The procedure of Contrasting is not linked with the USLIIS 10 point system. It is a part of Mental Contrasting with Implementation Intentions (MCII). Therefore, the statement given in the question is false.
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The rectus abdominis muscle: a. Concentrically causes the spine to move in the sagital plane.
b. Eccentrically controls lumbar flexion.
c. Is the best abdominal muscle to produce spine rotation.
d. Is part of a force couple to produce an anterior pelvic tilt.
Option C: The rectus abdominis muscle is the best abdominal muscle to produce spine rotation.
The rectus abdominis muscle, commonly known as the "six-pack" muscle, is a paired muscle that runs vertically along the front of the abdomen. While it does have other functions, such as providing core stability and assisting in maintaining posture, it is primarily responsible for spinal flexion and rotation.
During spine rotation, the rectus abdominis muscle on one side contracts concentrically while the opposite side contracts eccentrically, creating a twisting motion. This action allows the spine to rotate in the transverse plane, which is the plane of movement where rotation occurs. Therefore, it is indeed the primary muscle involved in spine rotation.
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What are the three regions of the inner ear? List and describe the sensory units found in these three areas, and indicate a disorder/disease that impacts each one.
The three regions of the inner ear are the cochlea, the vestibule, and the semicircular canals. These areas have various sensory units that have unique functions. Below is a list of sensory units found in each of the three areas along with a disorder/disease that impacts each one:
1. Cochlea: The cochlea contains the sensory unit called the Organ of Corti. It is responsible for transmitting auditory signals to the brain, where they are interpreted as sound. Cochlear deafness is an example of a disorder that affects this sensory unit. It is a condition that causes a loss of hearing sensitivity in the cochlea.
2. Vestibule: The vestibule contains the sensory unit called the macula. It is responsible for transmitting information about head position and acceleration to the brain. Benign Paroxysmal Positional Vertigo (BPPV) is a disorder that affects this sensory unit. It is a condition that causes vertigo and dizziness due to the presence of tiny calcium carbonate crystals in the inner ear.
3. Semicircular canals: The semicircular canals contain the sensory units called cristae. It is responsible for transmitting information about head rotation to the brain. The disorder that affects this sensory unit is called Vestibular Neuritis. It is a condition that causes inflammation of the vestibular nerve, resulting in dizziness, vertigo, and balance problems.
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The amount of testosterone and sperm produced by the testes is dependent on the influence of?
The amount of testosterone and sperm produced by the testes is dependent on the influence of the hypothalamus-pituitary-gonadal (HPG) axis.
The hypothalamus secretes gonadotropin-releasing hormone (GnRH), which stimulates the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH).These hormones act on the testes, encouraging testosterone and sperm production. The amount of testosterone and sperm produced in the testes is also influenced by the presence of Leydig and Sertoli cells. Leydig cells are responsible for producing testosterone, while Sertoli cells assist in the maturation of sperm.
The production of testosterone and sperm is tightly regulated by feedback mechanisms within the HPG axis. When testosterone levels are low, the hypothalamus releases more GnRH, which stimulates the pituitary gland to secrete FSH and LH, thereby increasing testosterone and sperm production. Conversely, high levels of testosterone exert negative feedback on the hypothalamus and pituitary, leading to a decrease in GnRH, FSH, and LH release, and subsequently reducing testosterone and sperm production.
Overall, the HPG axis serves as a regulatory system controlling the production of testosterone and sperm, maintaining the balance necessary for male reproductive function.
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Laboratory Review Worksheet Part 1: Lab Q & A 1. What is the difference between the zygomatic process and the zygomatic arch? 2. List the four cranial bones that contain sinuses. 1.... 2.... 3..... 4..... 3. What are the two main functions of fontanelles? 1.... 2.... 4. Fill in the table. Structure Significance 1. Passageway for the internal carotid artery
Foramen magnum 2. Passageway for 3. Passageway for cranial nerve
Optic canal 4. Passageway for 5. Choose which type of vertebrae has the characteristic (select choices more than once) a. Cervical b. Thoracic c. Lumbar d. All a, b, and c 1. Transverse foramen 2. Costal facets 3. Bifid (split) spinous process 4. Broad, flat spinous process 6. An excessive thoracic curvature of the spine is known as a. lordosis b. kyphosis C. scoliosis 7. Which intervertebral ligament attaches to the posterior portion of each vertebral body? a. interspinous c. supraspinous b. anterior longitudinal d. posterior longitudinal
1. The zygomatic process is part of the zygomatic arch.
2. The frontal, ethmoid, sphenoid, and maxillary bones contain sinuses.
3. Fontanelles allow skull flexibility during childbirth and accommodate brain growth in infants.
4. Structures like the foramen magnum and optic canal serve as passageways for arteries, nerves, and cerebrospinal fluid.
5. Different types of vertebrae have distinct features, such as transverse foramen in cervical vertebrae and costal facets in thoracic vertebrae.
6. Excessive thoracic curvature is called kyphosis.
7. The supraspinous ligament attaches to the posterior vertebral bodies.
1. The zygomatic process is a projection of the temporal bone that forms part of the zygomatic arch. The zygomatic arch, on the other hand, is a bony structure formed by the temporal bone and the zygomatic bone. In summary, the zygomatic process is a component of the zygomatic arch.
2. The four cranial bones that contain sinuses are:
1. Frontal bone
2. Ethmoid bone
3. Sphenoid bone
4. Maxillary bone
3. The two main functions of fontanelles (also known as "soft spots") are:
1. Allow for flexibility and compression of the skull during childbirth.
2. Accommodate rapid brain growth in infants by providing room for brain expansion.
4. Structure Significance
1. Foramen magnum Passageway for the internal carotid artery and the spinal cord.
2. Optic canal Passageway for the optic nerve and ophthalmic artery.
3. Cranial nerve Passageway for various cranial nerves.
4. Fourth ventricle Passageway for cerebrospinal fluid (CSF) circulation.
5. The characteristic features of the different types of vertebrae are as follows:
- Cervical: Transverse foramen, bifid (split) spinous process.
- Thoracic: Costal facets, long and downward-pointing spinous process.
- Lumbar: Broad, flat spinous process.
- All a, b, and c: Cervical, thoracic, and lumbar vertebrae share some of these characteristics.
6. An excessive thoracic curvature of the spine is known as **b. kyphosis**. Lordosis refers to excessive inward curvature of the lumbar spine, while scoliosis is an abnormal lateral curvature of the spine.
7. The intervertebral ligament that attaches to the posterior portion of each vertebral body is the **c. supraspinous** ligament. The anterior longitudinal ligament attaches to the anterior portion of the vertebral bodies, the posterior longitudinal ligament runs within the vertebral canal along the posterior aspect of the vertebral bodies, and the interspinous ligament connects adjacent spinous processes.
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Which of the following statements about protein synthesis is NOT TRUE? a. Transcription occurs in the ribosome of the cell. b. DNA directs the cell to carry out the process. c. RNA is single-stranded and travels outside the nucleus. d. In RNA, the pyrimidine base thymine is replaced with uracil.
The following statement about protein synthesis that is NOT TRUE is "Transcription occurs in the ribosome of the cell."
What is protein synthesis?Protein synthesis is a process by which biological cells produce new proteins. The process takes place in two stages: transcription and translation.The correct options are:a. Transcription occurs in the ribosome of the cell - False. Transcription is the process by which a DNA sequence is converted into an RNA molecule. This process occurs in the cell nucleus and not the ribosome of the cell.
DNA directs the cell to carry out the process - True. DNA contains the genetic code that directs the synthesis of proteins in the cell. RNA is single-stranded and travels outside the nucleus - True. RNA is single-stranded and travels outside the nucleus, to the ribosome, where protein synthesis occurs.
In RNA, the pyrimidine base thymine is replaced with uracil - True. RNA contains four nitrogenous bases, adenine (A), guanine (G), cytosine (C), and uracil (U). RNA does not contain thymine (T). It is replaced by uracil (U).Therefore, the correct answer is: a. Transcription occurs in the ribosome of the cell.
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39 3 points In the male, LH assists in spermatogenesis and stimulates the production of: A. Secondary sexual characteristic. B.Ejaculation C. Testosterone. D. GnRH. 403 points All of the following are part of the spermatic cord, EXCEPT: A. Testicular artery B.Lymphatic vessels C. Cremaster muscle. D. Ductus deferens. E. Ejaculatory duct 41 3 points The part of the female reproductive system "lost" during menstruation is? A. Myometrium. B. Stratum functionalis of the endometrium. C. Stratum basalis of the endometrium. D. Germinal epithelium.
a. Option C is correct.
b. Option E is correct.
c. Option B is correct.
a. LH aids in spermatogenesis in males and induces the synthesis of: Testosterone, in C.
LH stimulates the generation of testosterone by acting on the Leydig cells in the testes.
b. All of the items listed here, WITH THE EXCEPTION OF: E. The urinary duct.
The structure that connects the inguinal canal to the testicles is known as the spermatic cord. It has a number of parts that supply and sustain the testes. The testicular artery, lymphatic vessels, and ductus deferens are parts of the spermatic cord.
c. The endometrium's B. stratum functionalism is the portion of the female reproductive system that is "lost" during menstruation. The endometrium's stratum functionalism sheds during menstruation. The uterus's internal lining, known as the endometrium, is made up of
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Complete question
a. In the male, LH assists in spermatogenesis and stimulates the production of:
A. Secondary sexual characteristic.
B. Ejaculation
C. Testosterone.
D. GnRH.
b. All of the following are part of the spermatic cord, EXCEPT:
A. Testicular artery
B. Lymphatic vessels
C. Cremaster muscle.
D. Ductus deferens.
E. Ejaculatory duct
c. The part of the female reproductive system "lost" during menstruation is?
A. Myometrium.
B. Stratum functionalism of the endometrium.
C. Stratum basalis of the endometrium.
D. Germinal epithelium.
Systematically explain the functional significance of different
parts of the brain
The brain consists of the cerebral cortex, limbic system, basal ganglia, thalamus, brainstem, cerebellum, and corpus callosum, which collaboratively enable cognitive processes, emotional responses, motor control, sensory perception, and information integration.
Different parts of the brain are Cerebral Cortex, Limbic System, Basal Ganglia, Thalamus, Brainstem, Cerebellum, and Corpus Callosum.
The brain is a complex organ that consists of various parts, each with its own unique functions. Here is a systematic explanation of the functional significance of different parts of the brain:
Cerebral Cortex: The cerebral cortex is the outer layer of the brain and is responsible for higher cognitive functions such as thinking, reasoning, perception, and voluntary movement. It is divided into four lobes: frontal, parietal, temporal, and occipital. Each lobe has specific roles, for example:
Frontal lobe: It is involved in decision-making, problem-solving, and motor control.
Parietal lobe: It processes sensory information, spatial awareness, and perception.
Temporal lobe: It plays a role in memory, language processing, and auditory perception.
Occipital lobe: It is primarily responsible for visual processing.
Limbic System: The limbic system is a group of structures located deep within the brain and is involved in emotion, memory, and motivation.
Key components include the hippocampus (memory formation), amygdala (emotion and fear processing), and hypothalamus (regulation of basic drives like hunger, thirst, and sexual behavior).
Basal Ganglia: The basal ganglia are a group of structures involved in motor control, procedural learning, and habit formation. They help initiate and regulate voluntary movements and are also implicated in Parkinson's disease and other movement disorders.
Thalamus: The thalamus acts as a relay station for sensory information, directing signals to the appropriate areas of the cerebral cortex for processing. It is crucial for sensory perception, attention, and consciousness.
Brainstem: The brainstem is the oldest and most primitive part of the brain, responsible for vital functions necessary for survival, including regulating heartbeat, breathing, and maintaining basic levels of consciousness. It comprises the midbrain, pons, and medulla oblongata.
Cerebellum: The cerebellum is located at the back of the brain, below the cerebral cortex. It plays a critical role in coordinating and fine-tuning motor movements, maintaining balance and posture, and motor learning.
Corpus Callosum: The corpus callosum is a bundle of nerve fibers that connects the left and right hemispheres of the brain. It facilitates communication and information exchange between the two hemispheres, enabling integration of sensory and motor functions.
It's important to note that this is a simplified overview, and each brain region interacts with others to support complex cognitive and physiological processes.
The brain's functional significance arises from the intricate connections and interactions between these various parts, allowing for the integration of information, control of bodily functions, and the basis of our cognitive abilities.
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Draw the release pathway for the peptide hormone "Tognasol" under a condition of secondary hypersecretion. Tognasol release is under the control of the following complex endocrine pathway: Hypothalamus (synthesizes and releases TRH: Tognatropic Releasing Hormone), Pituitary (synthesizes and releases NSH: Nephrotognan Stimulating Hormone), Nephron (synthesizes and releases Tognasol which acts on the left ventricle of heart decreasing stress response. High plasma levels of Tognasol inhibit release of TRH and NSH. Label all glands/structures, name the most likely root cause of the hypersecretion, name and give relative concentrations of each hormone involved in the control pathway, show negative feedback loop and indicate if it is active/effective in this scenario. Indicate whether or not you would expect a goiter to be present. Indicate whether the first hormone in the release pathway would enter a portal system for delivery, or employ axonal transport.
The release pathway involves the hypothalamus, pituitary, and nephron, with elevated concentrations of TRH, NSH, and Tognasol due to hypersecretion. The high plasma levels of Tognasol inhibit the release of TRH and NSH through a negative feedback loop, indicating an ineffective feedback mechanism.
What is the release pathway for the peptide hormone "Tognasol" under the condition of secondary hypersecretion and its implications?The release pathway for the peptide hormone "Tognasol" under a condition of secondary hypersecretion involves the following glands/structures:
Hypothalamus (TRH synthesis and release), Pituitary (NSH synthesis and release), and Nephron (Tognasol synthesis and release). The root cause of hypersecretion is likely a dysfunction in the negative feedback loop.
In the control pathway, the concentrations of TRH, NSH, and Tognasol would be elevated due to hypersecretion.
However, the high plasma levels of Tognasol would inhibit the release of TRH and NSH through negative feedback. It indicates that the negative feedback loop is active but ineffective in this scenario.
A goiter is not expected to be present because Tognasol does not directly affect the thyroid gland.
The first hormone in the release pathway, TRH, would enter a portal system for delivery since it is released by the hypothalamus into the hypophyseal portal circulation.
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Question 11 2 pts Based on the baroreceptor reflex, state how the following would respond due to a decrease in blood pressure: [ Select] Stretch of Baroreceptors [ Select] Firing of Action potentials [ Select] Vasomotor Center [ Select] Cardio Acceleratory Center [ Select] Blood vessel diameter [ Select] Heart Rate [ Select] Stroke Volume
[ Select]Cardiac Output [ Select] Blood Pressure [ Select] : increase/decrease
Based on the baroreceptor reflex, stretch of baroreceptors would respond due to a decrease in blood pressure.
What is the baroreceptor reflex?
The baroreceptor reflex is a feedback loop that assists in the maintenance of blood pressure. It is a negative feedback system that operates in response to changes in blood pressure.
The baroreceptor reflex's primary goal is to maintain a steady blood pressure despite fluctuations in vascular resistance and cardiac output.
In the event of a decrease in blood pressure:
Stretch of Baroreceptors: It decreases the firing of action potentials. This is caused by reduced stretching of the carotid arteries' and aortic arches' baroreceptors, which detect changes in arterial pressure. The stimulation frequency of the afferent fibers reduces as baroreceptor activity decreases.
Vasomotor Center: It will respond by increasing sympathetic activity. When the baroreceptors detect a decrease in blood pressure, they generate less action potential activity, leading to a decrease in the frequency of inhibitory signals transmitted to the vasomotor center. This, in turn, increases sympathetic activity.
Cardio Acceleratory Center: It will be activated to increase cardiac output. A decrease in cardiac output activates the cardiac accelerator center in the medulla, which raises sympathetic activity and increases heart rate, contractility, and peripheral vascular resistance.
Blood Vessel Diameter: It decreases, as the sympathetic nervous system is activated, and vasoconstriction occurs, causing a decrease in vessel diameter.
Heart Rate: It increases due to sympathetic nervous system stimulation, leading to a rise in heart rate.
Stroke Volume: It increases because the increase in heart rate causes the heart to pump more blood.
Cardiac Output: It increases due to the increased heart rate and stroke volume.
Blood Pressure: It increases as a result of the increase in cardiac output and peripheral vascular resistance.
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zheng js, tang s, qi yk, wang zp, liu l (2013) chemical synthesis of proteins using peptide hydrazides as thioester surrogates. nat protoc 8(12):2483–2495.
The protocol outlines a thorough process for the native chemical ligation of peptide hydrazides to produce proteins.
A set of techniques known as chemical ligation is used to create long peptide or protein chains. In a convergent approach, it follows the first step. First, conventional chemical peptide synthesis produces smaller peptides between 30 and 50 amino acids in length. After that, they are completely vulnerable. Recombinant protein C-terminal thioesters often interact with synthetic peptides containing N-cysteine in a chemoselective ligation as part of the expressed protein ligation method for protein semisynthesis.
A simple method can be used to directly synthesise native backbone proteins of average size. The chemoselective reaction of two unprotected peptide segments results in the production of an initial thioester-linked species. This fleeting intermediate undergoes a spontaneous rearrangement to give rise to a fully developed product with a native peptide bond at the location of ligation.
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Complete Question:
Explain the chemical synthesis of proteins using peptide hydrazides as thioester surrogates. nat protoc 8(12):2483–2495. zheng js, tang s, qi yk, wang zp, liu l (2013)
What are the dark bands and light bands of a sarcomere?
What creates these dark bands and what creates the light bands?
What proteins are found here?
The dark bands of a sarcomere are called A bands while the light bands of a sarcomere are called I bands. The A band is created by the presence of both thick and thin filaments while the I band is created by the presence of thin filaments only.
The dark color of the A band is due to the presence of thick filaments that contain myosin protein, which interacts with the thin filaments made up of actin protein, to generate muscle contraction.
The light color of the I band is due to the presence of actin filaments only, which are anchored at their centers by a Z-disc or Z-line made of titin protein, while the ends of the thin filaments overlap with the thick filaments of the A band, creating a band known as the H-zone.
The following are the proteins found in the dark and light bands of a sarcomere:A band: myosin protein and ATPI band: actin protein, troponin, and tropomyosin.
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How
does exercixe (compression/tension) on the bones contribute to bone
deposition?
Exercise, tension, and compression on bones contribute to bone deposition by stimulating bone cells to rebuild and strengthen the bone tissue.
These mechanical stresses trigger a process called bone remodeling, which involves the breakdown of old bone tissue and the formation of new bone tissue by specialized cells called osteoblasts.Bone deposition occurs when osteoblasts synthesize collagen, a protein that provides the framework for bone tissue. They also secrete mineral ions like calcium and phosphate, which are deposited into the collagen matrix, creating new bone tissue. This process is essential for maintaining bone strength and preventing bone loss, particularly in weight-bearing bones like the spine and hips.
Regular exercise, particularly weight-bearing exercises like running and weightlifting, can help to maintain bone density and prevent osteoporosis in older adults. The mechanical stresses of these activities stimulate osteoblasts, which increases bone formation and deposition. Conversely, inactivity or immobilization, such as prolonged bed rest or space travel, can lead to bone loss and osteoporosis due to decreased mechanical stress on the bones.
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A. 45 -year -old female with a history of Type I diabetes mellitus developed marked proteinuria. What is the most likely histological finding in her kidney? A. Reflux nephropathy B. Diabetic nephropathy C. Acute Glomerulonephritis D. Nodular mesangial glomerulopathy
The most likely histological finding in the kidney of a 45-year-old female with a history of Type I diabetes mellitus and marked proteinuria is Diabetic nephropathy. Option B .
Diabetic nephropathy is a microvascular complication of diabetes that involves the kidney. It is caused by damage to the small blood vessels in the kidneys that are used to filter waste from the blood. Diabetic nephropathy, or diabetic kidney disease, is the leading cause of end-stage renal disease (ESRD) in the United States and other developed countries.
It is also a major cause of morbidity and mortality in people with diabetes. Therefore, the most likely histological finding in the kidney of a 45-year-old female with a history of Type I diabetes mellitus and marked proteinuria is Diabetic nephropathy. Option B is correct.
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Which of the following may increase the risk of breast cancer? a. Early menopause b. Having more than 3 children c. Becoming obese after menopause d. Breastfeeding
c) Becoming obese after menopause may increase the risk of breast cancer. Adipose tissue produces estrogen, and higher levels of estrogen after menopause can promote the development of breast cancer cells.
Becoming obese after menopause is associated with an increased risk of breast cancer. Adipose tissue, particularly in postmenopausal women, is a significant source of estrogen production. Estrogen can stimulate the growth of certain types of breast cancer cells. When women go through menopause, the ovaries produce less estrogen. However, adipose tissue continues to produce estrogen through the conversion of androgens to estrogen by the enzyme aromatase. With increased adiposity, there is a higher level of estrogen production, which can promote the development and growth of breast cancer cells. Therefore, obesity after menopause is considered a risk factor for breast cancer. It is important to note that other factors, such as genetics, hormonal factors, and lifestyle choices, can also influence breast cancer risk, and the interplay between these factors is complex.
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Timer 17. Which of the following structures of the brain is NOT connected to the reticular formation? Medulla Hypothalamus Substantia niagra Cerebellum Red nucleus Unaved save > O
The structure of the brain that is NOT connected to the reticular formation is the cerebellum. The cerebellum is located at the back of the brain and is responsible for coordination and balance. It helps to maintain posture and balance and is involved in the coordination of voluntary movements.
The medulla, hypothalamus, substantia niagra, and red nucleus are all connected to the reticular formation. The medulla oblongata is a part of the brainstem that controls many vital functions such as breathing and heart rate. The hypothalamus is involved in regulating many bodily functions including body temperature, hunger, thirst, and sleep. The substantia niagra is a part of the midbrain that is involved in the production of dopamine, a neurotransmitter that is involved in the control of movement. The red nucleus is another part of the midbrain that is involved in the control of movement.
Therefore, the cerebellum is the only structure of the brain among the given options that is NOT connected to the reticular formation.
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Describe a situation where utilizing predictive 1RM tests would
be applicable.
Predictive 1RM tests can be used in several situations, including creating training plans, tracking progress, and identifying strength imbalances.
However, a situation where utilizing predictive 1RM tests would be applicable is to determine the training intensity of a client who wants to increase their strength. A client wants to increase their strength, and you, as a trainer, want to determine the appropriate training intensity for them. To do this, you need to estimate the client's 1-rep max (1RM), which is the maximum weight they can lift for one repetition. However, testing a client's 1RM can be risky, especially if the client is new to lifting weights or lacks experience. So, in this situation, you can use predictive 1RM tests to estimate the client's 1RM. This test involves using a submaximal weight and calculating the predicted 1RM using an equation such as Epley's or Brzycki's formula. The result will give you a good idea of the client's strength level, which will help you design an appropriate training program that will help the client increase their strength while minimizing the risk of injury.
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Which bone is highlighted? which bone is highlighted? talus calcaneus navicular cuboid
The highlighted bone is the Talus. Option D is correct.
The talus is a large bone located in the ankle joint, between the tibia and fibula (lower leg bones) and the calcaneus (heel bone). It plays a crucial role in transmitting weight and forces from the lower leg to the foot during movement. The talus is unique in its shape and function, as it forms the main connection between the leg and the foot, allowing for the up-and-down movement of the foot.
The talus is a key component of the ankle joint, providing stability and facilitating movements such as dorsiflexion (lifting the foot upwards) and plantarflexion (pointing the foot downwards). It also contributes to inversion and eversion movements, which involve turning the foot inward and outward, respectively.
Hence, D. is the correct option.
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--The given question is incomplete, the complete question is
"Which Bone Is Highlighted? A) Cuboid B) Lateral Cuneiform C) Navicular D) Talus E) Medial Cuneiform."--
A powerful alien life force has just landed on Earth. Once detected, a fierce battle between the Army of Earth and the invading aliens ensues. As you read the description of the battle, relate the elements of the story to the components of the immune system. You’ll see that the roles of our immune cells and proteins directly relate to the people/tools/weapons of war!...
A Scout from the Earth Army is out patrolling the wilderness, searching for anything out of the ordinary. He suddenly stumbles upon something on the forest floor he’s never seen before so he picks it up and returns to Army headquarters. At headquarters he shows the General of the Army his secret ID (to prove he was a citizen of Earth) and the item he found. The General exclaims that the scout has found an Alien uniform! In response to this disturbing find, the General immediately sends orders to two companies of Army soldiers: a team of Chemical Warfare Specialists and a platoon of highly trained Warriors.
The Chemical Warfare Specialists take the General’s orders and the Alien uniform to their lab for further analysis. There they spend many hours developing a special toxin that only binds to Alien skin. When ready, the toxin is released by the Chemical Warfare Specialists into the atmosphere. Over the course of several days, many Aliens become incapacitated by the toxin and are forced to surrender. Meanwhile, the Warriors respond to the General's orders by infiltrating the Alien troops and battling them in hand-to-hand combat with razor-sharp swords.
Although the Earth Army suffered many casualties during the attack, they managed to save the world from alien invasion! However, knowing that more Aliens exist in the universe, the Army designates an elite group of Chemical Warfare Specialists to stand by – always prepared to make more of their alien toxin at a moment's notice in case the Alien force dares to return.
Relate the elements of this story to the components of the immune system listed below.
Match the people in the story (1-7) with the cells of the immune system (A-G).
Match the tools/weapons in the story (8-12) with the proteins involved in the immune response (H-L).
1. Earth Army _____
2. Klingons _____
3. Army scout _____
4. General of the Army _____
5. Chemical Warfare Specialists _____
6. Marine foot soldiers _____
7. elite group of Chemical Warfare Specialists _____
________________________________________
8. Secret ID of Army scout _____
9. Klingon uniform _____
10. General's orders _____
11. toxin made by Chemical Warfare Specialists ____
12. razor-sharp swords of Marines _____
A. immune system
B. B cells/plasma cells
C. memory B cells
D. cytotoxic T cells
E. helper T cells
F. antigen-presenting cells
G. pathogen
H. interleukins
I. foreign antigen
J. perforins
K. MHC proteins
L. antibodies
The immune system is very similar to the war components described in the story. In the story, the components of the immune system are the alien and the army soldiers who are fighting against each other.
The immune system comprises different types of cells and proteins that work together to identify, destroy, and remove invading pathogens from the body. The cells of the immune system can be categorized into two types: B cells and T cells. B cells are responsible for producing antibodies, while T cells are responsible for attacking and killing infected cells. The proteins of the immune system are cytokines, complement proteins, and antibodies. These proteins have different roles in the immune response. The Earth's army is analogous to the immune system because it is responsible for defending the body from invading pathogens. The following are the matches between the people in the story and the cells of the immune system:1. Earth Army: immune system2. Klingons: pathogens3. Army scout: antigen-presenting cells4. General of the Army: helper T cells5. Chemical Warfare Specialists: B cells/plasma cells6. Marine foot soldiers: cytotoxic T cells7. elite group of Chemical Warfare Specialists: memory B cells The following are the matches between the tools/weapons in the story and the proteins involved in the immune response:8. Secret ID of Army scout: foreign antigen9. Klingon uniform: pathogen10. General's orders: interleukins11. toxin made by Chemical Warfare Specialists: antibodies12. razor-sharp swords of Marines: perforins
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Two equal volumes of liquid are added to a chamber, separated by a semipermeable membrane. Water molecules (and only water molecules) can pass easily through the membrane. On one side (Side A) the liquid is pure water. On the other (Side B) the solution contains a high concentration of salt (NaCl) in water. After two hours, you observe that the water level on Side B is higher than on Side A. Which of the following best explains this result? O Water molecules repel each other, and diffuse away from areas of high concentration of water O Solute particles bound to water molecules, move away from a membrane impermeable to the solute, pulling water molecules across the membrane permeable to water. O Water molecules attract each other, and form bonds between water molecules that are stronger than those between water and the solute particles, drawing water toward areas of high solute concentration where water-solute bonds break and water-water bonds form. O Water molecules form stronger bonds with solute particles, than with neighboring water molecules, pulling water molecules across the membrane toward high concentrations of solute particles.
After two hours, you observe that the water level on Side B is higher than on Side A. The statement (c) is the best explains this result.
This observation can be best explained as follows: Water molecules attract each other, and form bonds between water molecules that are stronger than those between water and the solute particles, drawing water toward areas of high solute concentration (The substance that dissolves in a solution is called the solute, and the substance that does the dissolving is called the solvent. The concentration of a solution is the amount of solute in a given amount of solution) where water-solute bonds break and water-water bonds form. In this scenario, water molecules attract each other and form hydrogen bonds. This hydrogen bonding is why the water level in side B is higher than side A.
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The full question is
Two equal volumes of liquid are added to a chamber, separated by a semipermeable membrane. Water molecules (and only water molecules) can pass easily through the membrane. On one side (Side A) the liquid is pure water. On the other (Side B) the solution contains a high concentration of salt (NaCl) in water. After two hours, you observe that the water level on Side B is higher than on Side A. Which of the following best explains this result?
(A) Water molecules repel each other, and diffuse away from areas of high concentration of water
(b) Solute particles bound to water molecules, move away from a membrane impermeable to the solute, pulling water molecules across the membrane permeable to water.
(c) Water molecules attract each other, and form bonds between water molecules that are stronger than those between water and the solute particles, drawing water toward areas of high solute concentration where water-solute bonds break and water-water bonds form.
(D) Water molecules form stronger bonds with solute particles, than with neighboring water molecules, pulling water molecules across the membrane toward high concentrations of solute particles.
An otherwise healthy, 72 year-old man has had increasing difficulty with urination for the past 10 years. He now has to get up several times each night because of a feeling of urgency, but each time the urine volume is not great. He has difficulty starting and stopping urination. On physical examination, the prostate is enlarged to twice its normal size. One year ago, his serum prostate specific antigen (PSA) level was 6 ng/mL, and it is still at that level when retested. Which of the following is the most likely diagnosis?
(Normal range of PSA: Men aged 70 and above: 0 to 5.0 ng/mL for Asian Americans, 0 to 5.5 ng/mL for African Americans, and 0 to 6.5 ng/mL for Caucasians)
a) Prostate cancer
b) Hydrocele
c) Benign prostatic hyperplasia
d) Orchitis
The correct option is c) Benign prostatic hyperplasia (BPH). Based on the given information, the most likely diagnosis for this 72-year-old man is Benign prostatic hyperplasia (BPH).
Benign prostatic hyperplasia (BPH) is the most probable diagnosis for an otherwise healthy 72-year-old man who has had increasing difficulty with urination for the past ten years. BPH, prostate cancer, hydrocele, and orchitis are all distinct medical illnesses. BPH is a benign (non-cancerous) growth of the prostate gland's epithelial and stromal components.
The prostate, located beneath the bladder in males, produces semen components that help maintain the sperm in liquid form and prevent the immune system from attacking them. An enlarged prostate gland caused by BPH can impede the normal flow of urine, resulting in incomplete bladder emptying, weak urine flow, and other related symptoms. The prostate-specific antigen (PSA) blood test, which measures PSA levels in the blood, can help determine if the man is suffering from BPH or prostate cancer.
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What is the best definition for mineral nutrients?
1. Inorganic substances required for life
2. Organic substances required for life
3. Micronutrient substances required for life
4. Macronutrient substances required for life
The best definition for mineral nutrients is that they are inorganic substances required for life.The correct answer is option 1.
Mineral nutrients are inorganic nutrients that are vital for proper health, growth, and development. They're known as essential minerals since they're required for a variety of bodily processes that sustain life. Some of these nutrients play a significant role in various physiological functions, such as electrolyte regulation, cell function, blood clotting, and bone strength.Most of the minerals that humans need can be found in the soil and in the foods that we eat. However, some people may not consume enough of certain minerals, such as iron or calcium, in their diets, leading to mineral deficiencies. In these instances, doctors may recommend mineral supplements to help correct the deficiency.The correct answer is option 1.
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Q.1. Compare and contrast volatile and nonvolatile body acids. Be sure to
provide specific examples of each type and explain how thev are formed
within the body. Make sure you address the normal functions of the acids
and their role in maintaining body pH.
Q.2. What are common signs/symptoms (manifestations) that would cause
health care professionals to suspect a patient is experiencing acidosis?
What are common signs/symptoms (manifestations) that would cause
health care professionals to suspect a patient is experiencing alkalosis?
Pick two sign/symptoms and explain why they are occurring.
Volatile and non-volatile acids are the two types of acids that exist in the human body.
Volatile acids: These are weak acids that can vaporize and excrete through the lungs. Carbon dioxide is an example of a volatile acid. The metabolism of carbohydrates and fats produces carbon dioxide in the body, which mixes with water to form carbonic acid.HCO₃⁻ + H⁺ → H₂CO₃ → H₂O + CO₂
Nonvolatile acids: These are non-volatile and solid, and they do not vaporize and excrete through the lungs. Lactic acid, sulfuric acid, and hydrochloric acid are some examples of nonvolatile acids that are produced in the body during metabolism.
Example of Lactic acid formation:During anaerobic metabolism, skeletal muscle fibers produce lactic acid when there is a shortage of oxygen. The metabolism of glucose forms two pyruvic acid molecules, which are then converted to lactic acid. Therefore, lactic acidosis is a prevalent condition in individuals who have circulatory or respiratory disorders and cannot adequately deliver oxygen to the body cells.
Acidosis: Acidosis is a condition characterized by a low blood pH. Confusion, drowsiness, shortness of breath, tremors, and a fruity odor to the breath are some of the most typical symptoms of acidosis.Confusion, drowsiness: The build-up of acidic waste in the body impairs brain function. Consequently, patients may experience confusion, sleepiness, or lethargy.
Shortness of breath: Acidosis causes the lungs to work harder to inhale and exhale, which leads to shortness of breath and shallow breathing.Fruity odor to the breath: When the body is unable to utilize glucose for energy, it begins to burn fat, which produces ketones. Ketones in the blood produce a fruity odor that can be detected on the breath of the patient.
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What direct effect, if any, does Aldosterone have on the following?
A) sodium retention in the kidneys.
C) blood volume.
D) urinary sodium.
E) pH regulation.
Aldosterone is a hormone that is produced by the adrenal cortex, which is a part of the adrenal gland. Aldosterone has a direct effect on sodium retention in the kidneys. When aldosterone is present, it enhances the absorption of sodium ions in the kidney tubules, which results in an increase in sodium retention by the kidneys.
This is important for maintaining electrolyte balance in the body and regulating blood pressure. The direct effect of aldosterone on the other options is as follows:C) Blood volume: Aldosterone indirectly affects blood volume by regulating the retention of sodium ions in the kidneys. An increase in sodium retention leads to an increase in blood volume.D) Urinary sodium: Aldosterone decreases the amount of sodium that is excreted in urine. This is because it increases the reabsorption of sodium in the kidney tubules.E) pH regulation: Aldosterone has no direct effect on pH regulation. It primarily affects sodium and electrolyte balance in the body. However, changes in sodium and electrolyte balance can indirectly affect pH regulation.
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During a push up, indicate the plane and axis for each joint
(shoulder, elbow, hand/wrist).
During a push-up, the plane and axis for each joint is as follows:Shoulder Joint: The plane of movement for the shoulder joint during a push-up is sagittal, which is also referred to as the anteroposterior plane.
The axis of rotation is in a horizontal plane that passes through the joint center. This axis is also known as the mediolateral axis.Elbow Joint: The plane of movement for the elbow joint during a push-up is sagittal. The axis of rotation is in the frontal plane that passes through the joint center. This axis is also known as the anteroposterior axis.Hand/Wrist Joint: The plane of movement for the hand/wrist joint during a push-up is transverse, which is also referred to as the horizontal plane. The axis of rotation is in a longitudinal plane that passes through the joint center. This axis is also known as the vertical axis.
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The chemical called EDTA chelates calcium ions? Explain at which
level in the pathway, and why EDTA would affect blood
clotting!
EDTA (ethylenediaminetetraacetic acid) is a chelating agent that can form stable complexes with metal ions such as calcium, which is required for blood clotting. EDTA would therefore affect blood clotting by chelating calcium ions and rendering them unavailable for the coagulation cascade.
EDTA affects blood clotting at the level of coagulation cascade. Calcium ions play an important role in blood coagulation by acting as a cofactor in the activation of several clotting factors, including Factor X, prothrombin, and Factor VII. Therefore, if calcium is chelated by EDTA, it is unable to act as a cofactor, resulting in decreased blood clotting.
EDTA would affect blood clotting because it can chelate calcium ions. Calcium is an essential cofactor in blood clotting; it is required for the activation of several clotting factors. When calcium is chelated by EDTA, it is no longer available to act as a cofactor, which can lead to decreased clotting activity. Therefore, EDTA may be used as an anticoagulant by removing calcium ions from the clotting reaction.
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